Efficacy and safety of vitamin K-antagonists (VKA) for atrial fibrillation in non-dialysis dependent chronic kidney disease

Essential information regarding efficacy and safety of vitamin K-antagonists (VKA) treatment for atrial fibrillation (AF) in non-dialysis dependent chronic kidney disease (CKD) is still lacking in current literature. The aim of our study was to compare the risks of stroke or transient ischemic attac...

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Bibliographic Details
Published in:PloS one 2014-05, Vol.9 (5), p.e94420
Main Authors: Kooiman, Judith, van Rein, Nienke, Spaans, Bas, van Beers, Koen A J, Bank, Jonna R, van de Peppel, Wilke R, del Sol, Antonio Iglesias, Cannegieter, Suzanne C, Rabelink, Ton J, Lip, Gregory Y H, Klok, Frederikus A, Huisman, Menno V
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Analysis
Antagonists
Anticoagulants
Anticoagulants - adverse effects
Anticoagulants - therapeutic use
Atrial fibrillation
Atrial Fibrillation - complications
Atrial Fibrillation - drug therapy
Biology and Life Sciences
Bleeding
Cardiac arrhythmia
Care and treatment
Chronic kidney failure
Comorbidity
Dialysis
Effectiveness
Epidermal growth factor receptors
Female
Fibrillation
Follow-Up Studies
Growth rate
Health aspects
Health risks
Hemodialysis
Hemorrhage - chemically induced
Hospitals
Humans
Internal medicine
Ischemia
Ischemic Attack, Transient - chemically induced
Kidney diseases
Kidney transplantation
Male
Medical records
Medicine and Health Sciences
Middle Aged
Mortality
Multivariate Analysis
Patients
Proportional Hazards Models
Regression analysis
Renal Dialysis
Renal function
Renal Insufficiency, Chronic - complications
Risk Assessment - statistics & numerical data
Risk Factors
Safety
Stroke
Stroke - chemically induced
Stroke patients
Thrombosis
Transient ischemic attack
Treatment Outcome
Vitamin K
Vitamin K - antagonists & inhibitors
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Summary:Essential information regarding efficacy and safety of vitamin K-antagonists (VKA) treatment for atrial fibrillation (AF) in non-dialysis dependent chronic kidney disease (CKD) is still lacking in current literature. The aim of our study was to compare the risks of stroke or transient ischemic attack (TIA) and major bleeds between patients without CKD (eGFR >60 ml/min), and those with moderate (eGFR 30-60 ml/min), or severe non-dialysis dependent CKD (eGFR
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0094420