Neural correlates of alerting and orienting impairment in multiple sclerosis patients

A considerable percentage of multiple sclerosis patients have attentional impairment, but understanding its neurophysiological basis remains a challenge. The Attention Network Test allows 3 attentional networks to be studied. Previous behavioural studies using this test have shown that the alerting...

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Bibliographic Details
Published in:PloS one 2014-05, Vol.9 (5), p.e97226-e97226
Main Authors: Vázquez-Marrufo, Manuel, Galvao-Carmona, Alejandro, González-Rosa, Javier J, Hidalgo-Muñoz, Antonio R, Borges, Mónica, Ruiz-Peña, Juan Luis, Izquierdo, Guillermo
Format: Article
Language:English
Subjects:
Adult
Alzheimer's disease
Alzheimers disease
Analysis
Attention
Auditory evoked potentials
Biology and Life Sciences
Cognitive ability
Correlation
Correlation analysis
Demyelination
Dopamine
Event-related potentials
Evoked Potentials
Experimental psychology
Female
Humans
Impairment
Information processing
Latency
Male
Medicine and Health Sciences
Multiple sclerosis
Multiple Sclerosis - physiopathology
Neurophysiology
Neuropsychological Tests
Orientation
Patients
Psychology
Recurrence
Sensory integration
Social Sciences
Statistical analysis
Studies
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Summary:A considerable percentage of multiple sclerosis patients have attentional impairment, but understanding its neurophysiological basis remains a challenge. The Attention Network Test allows 3 attentional networks to be studied. Previous behavioural studies using this test have shown that the alerting network is impaired in multiple sclerosis. The aim of this study was to identify neurophysiological indexes of the attention impairment in relapsing-remitting multiple sclerosis patients using this test. After general slowing had been removed in patients group to isolate the effects of each condition, some behavioral differences between them were obtained. About Contingent Negative Variation, a statistically significant decrement were found in the amplitude for Central and Spatial Cue Conditions for patient group (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0097226