Correlations between integrin ανβ6 expression and clinico-pathological features in stage B and stage C rectal cancer

Integrin ανβ6 is highly expressed in a range of human cancers and frequently correlates with patient survival. This study examines correlations between ανβ6 expression and patient clinico-pathological features in Stage B and Stage C rectal cancer, including overall survival. Expression of ανβ6 was m...

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Bibliographic Details
Published in:PloS one 2014-05, Vol.9 (5), p.e97248-e97248
Main Authors: Ahn, Seong Beom, Mohamedali, Abidali, Chan, Charles, Fletcher, Julie, Kwun, Sun Young, Clarke, Candice, Dent, Owen F, Chapuis, Pierre H, Nice, Edouard, Baker, Mark S
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Antigens, Neoplasm - metabolism
Biology and Life Sciences
Biomarkers
Cancer
Cancer therapies
Colorectal cancer
Colorectal surgery
Correlation
Correlation analysis
Gene Expression Regulation, Neoplastic
Hospitals
Humans
Immunohistochemistry
Integrins - metabolism
Invasiveness
Kinases
Male
Medical prognosis
Medicine and Health Sciences
Metastasis
Middle Aged
Mucosa
Neoplasm Invasiveness
Neoplasm Staging
Pathology
Patients
Proteins
Rectal Neoplasms - metabolism
Rectal Neoplasms - pathology
Rectum
Survival
Survival Analysis
Tumors
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Summary:Integrin ανβ6 is highly expressed in a range of human cancers and frequently correlates with patient survival. This study examines correlations between ανβ6 expression and patient clinico-pathological features in Stage B and Stage C rectal cancer, including overall survival. Expression of ανβ6 was measured in 362 Stage B or C rectal cancer tissue samples at the tumour central region, invasive tumour front and adjacent non-neoplastic mucosa using immunohistochemistry. Distribution of ανβ6 was found to be significantly higher at the invasive front compared to central regions of the tumour (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0097248