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Comprehensive reference ranges for hematology and clinical chemistry laboratory parameters derived from normal Nigerian adults
Interpretation of laboratory test results with appropriate diagnostic accuracy requires reference or cutoff values. This study is a comprehensive determination of reference values for hematology and clinical chemistry in apparently healthy voluntary non-remunerated blood donors and pregnant women. C...
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| Published in: | PloS one 2014-05, Vol.9 (5), p.e93919-e93919 |
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| creator | Miri-Dashe, Timzing Osawe, Sophia Tokdung, Monday Daniel, Monday Tokdung Nenbammun Daniel, Nenbammun Choji, Rahila Pam Mamman, Ille Deme, Kurt Damulak, Dapus Abimiku, Alash'le |
| description | Interpretation of laboratory test results with appropriate diagnostic accuracy requires reference or cutoff values. This study is a comprehensive determination of reference values for hematology and clinical chemistry in apparently healthy voluntary non-remunerated blood donors and pregnant women.
Consented clients were clinically screened and counseled before testing for HIV, Hepatitis B, Hepatitis C and Syphilis. Standard national blood donors' questionnaire was administered to consented blood donors. Blood from qualified volunteers was used for measurement of complete hematology and chemistry parameters. Blood samples were analyzed from a total of 383 participants, 124 (32.4%) males, 125 (32.6%) non-pregnant females and 134 pregnant females (35.2%) with a mean age of 31 years. Our results showed that the red blood cells count (RBC), Hemoglobin (HB) and Hematocrit (HCT) had significant gender difference (p = 0.000) but not for total white blood count (p>0.05) which was only significantly higher in pregnant verses non-pregnant women (p = 0.000). Hemoglobin and Hematocrit values were lower in pregnancy (P = 0.000). Platelets were significantly higher in females than men (p = 0.001) but lower in pregnant women (p = .001) with marked difference in gestational period. For clinical chemistry parameters, there was no significant difference for sodium, potassium and chloride (p>0.05) but gender difference exists for Bicarbonate (HCO3), Urea nitrogen, Creatinine as well as the lipids (p |
| doi_str_mv | 10.1371/journal.pone.0093919 |
| format | article |
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Consented clients were clinically screened and counseled before testing for HIV, Hepatitis B, Hepatitis C and Syphilis. Standard national blood donors' questionnaire was administered to consented blood donors. Blood from qualified volunteers was used for measurement of complete hematology and chemistry parameters. Blood samples were analyzed from a total of 383 participants, 124 (32.4%) males, 125 (32.6%) non-pregnant females and 134 pregnant females (35.2%) with a mean age of 31 years. Our results showed that the red blood cells count (RBC), Hemoglobin (HB) and Hematocrit (HCT) had significant gender difference (p = 0.000) but not for total white blood count (p>0.05) which was only significantly higher in pregnant verses non-pregnant women (p = 0.000). Hemoglobin and Hematocrit values were lower in pregnancy (P = 0.000). Platelets were significantly higher in females than men (p = 0.001) but lower in pregnant women (p = .001) with marked difference in gestational period. For clinical chemistry parameters, there was no significant difference for sodium, potassium and chloride (p>0.05) but gender difference exists for Bicarbonate (HCO3), Urea nitrogen, Creatinine as well as the lipids (p<0.05). Total bilirubin was significantly higher in males than females (p = 0.000). Significant differences exist for all chemistry parameters between pregnant and non-pregnant women in this study (p<0.05), except Amylase and total cholesterol (p>0.05).
Hematological and Clinical Chemistry reference ranges established in this study showed significant gender differences. Pregnant women also differed from non-pregnant females and during pregnancy. This is the first of such comprehensive study to establish reference values among adult Nigerians and difference observed underscore the need to establish reference values for different populations.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0093919</identifier><identifier>PMID: 24832127</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescent ; Adult ; Adults ; Aged ; Bicarbonates ; Bilirubin ; Biochemistry ; Biology and Life Sciences ; Blood ; Blood & organ donations ; Blood cells ; Blood donation ; Blood Donors ; Blood transfusions ; Carbonates ; Chemistry ; Chemistry, Clinical - standards ; Cholesterol ; Clients ; Creatinine ; Cross-Sectional Studies ; Diagnostic systems ; Erythrocyte Count ; Erythrocytes ; Female ; Females ; Gender aspects ; Hematocrit ; Hematologic Tests - methods ; Hematology ; Hematology - standards ; Hemoglobin ; Hemoglobins ; Hepatitis ; Hepatitis B ; Hepatitis B - blood ; Hepatitis C ; Hepatitis C - blood ; HIV ; HIV Infections - blood ; HIV tests ; Hospitals ; Human immunodeficiency virus ; Humans ; Industrialized nations ; Laboratories ; Laboratory tests ; Leukocyte Count ; Lipids ; Male ; Males ; Medicine and Health Sciences ; Middle Aged ; Nigeria ; Physical Sciences ; Platelets ; Population ; Potassium ; Pregnancy ; Pregnant women ; Reference Values ; Research and Analysis Methods ; Rural areas ; Sex differences ; Sex Factors ; Sexually transmitted diseases ; Sodium ; STD ; Studies ; Syphilis ; Syphilis - blood ; Urea ; Virology ; Young Adult</subject><ispartof>PloS one, 2014-05, Vol.9 (5), p.e93919-e93919</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Miri-Dashe et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Miri-Dashe et al 2014 Miri-Dashe et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-563334e301d106949d59e9c6e4b5be619da8047be609a24d2719e66f50db6cc23</citedby><cites>FETCH-LOGICAL-c692t-563334e301d106949d59e9c6e4b5be619da8047be609a24d2719e66f50db6cc23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1524876211/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1524876211?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24832127$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Hartshorn, Kevan L.</contributor><creatorcontrib>Miri-Dashe, Timzing</creatorcontrib><creatorcontrib>Osawe, Sophia</creatorcontrib><creatorcontrib>Tokdung, Monday</creatorcontrib><creatorcontrib>Daniel, Monday Tokdung Nenbammun</creatorcontrib><creatorcontrib>Daniel, Nenbammun</creatorcontrib><creatorcontrib>Choji, Rahila Pam</creatorcontrib><creatorcontrib>Mamman, Ille</creatorcontrib><creatorcontrib>Deme, Kurt</creatorcontrib><creatorcontrib>Damulak, Dapus</creatorcontrib><creatorcontrib>Abimiku, Alash'le</creatorcontrib><title>Comprehensive reference ranges for hematology and clinical chemistry laboratory parameters derived from normal Nigerian adults</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Interpretation of laboratory test results with appropriate diagnostic accuracy requires reference or cutoff values. This study is a comprehensive determination of reference values for hematology and clinical chemistry in apparently healthy voluntary non-remunerated blood donors and pregnant women.
Consented clients were clinically screened and counseled before testing for HIV, Hepatitis B, Hepatitis C and Syphilis. Standard national blood donors' questionnaire was administered to consented blood donors. Blood from qualified volunteers was used for measurement of complete hematology and chemistry parameters. Blood samples were analyzed from a total of 383 participants, 124 (32.4%) males, 125 (32.6%) non-pregnant females and 134 pregnant females (35.2%) with a mean age of 31 years. Our results showed that the red blood cells count (RBC), Hemoglobin (HB) and Hematocrit (HCT) had significant gender difference (p = 0.000) but not for total white blood count (p>0.05) which was only significantly higher in pregnant verses non-pregnant women (p = 0.000). Hemoglobin and Hematocrit values were lower in pregnancy (P = 0.000). Platelets were significantly higher in females than men (p = 0.001) but lower in pregnant women (p = .001) with marked difference in gestational period. For clinical chemistry parameters, there was no significant difference for sodium, potassium and chloride (p>0.05) but gender difference exists for Bicarbonate (HCO3), Urea nitrogen, Creatinine as well as the lipids (p<0.05). Total bilirubin was significantly higher in males than females (p = 0.000). Significant differences exist for all chemistry parameters between pregnant and non-pregnant women in this study (p<0.05), except Amylase and total cholesterol (p>0.05).
Hematological and Clinical Chemistry reference ranges established in this study showed significant gender differences. Pregnant women also differed from non-pregnant females and during pregnancy. This is the first of such comprehensive study to establish reference values among adult Nigerians and difference observed underscore the need to establish reference values for different populations.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Adults</subject><subject>Aged</subject><subject>Bicarbonates</subject><subject>Bilirubin</subject><subject>Biochemistry</subject><subject>Biology and Life Sciences</subject><subject>Blood</subject><subject>Blood & organ donations</subject><subject>Blood cells</subject><subject>Blood donation</subject><subject>Blood Donors</subject><subject>Blood transfusions</subject><subject>Carbonates</subject><subject>Chemistry</subject><subject>Chemistry, Clinical - standards</subject><subject>Cholesterol</subject><subject>Clients</subject><subject>Creatinine</subject><subject>Cross-Sectional Studies</subject><subject>Diagnostic systems</subject><subject>Erythrocyte Count</subject><subject>Erythrocytes</subject><subject>Female</subject><subject>Females</subject><subject>Gender aspects</subject><subject>Hematocrit</subject><subject>Hematologic Tests - methods</subject><subject>Hematology</subject><subject>Hematology - standards</subject><subject>Hemoglobin</subject><subject>Hemoglobins</subject><subject>Hepatitis</subject><subject>Hepatitis B</subject><subject>Hepatitis B - blood</subject><subject>Hepatitis C</subject><subject>Hepatitis C - blood</subject><subject>HIV</subject><subject>HIV Infections - blood</subject><subject>HIV tests</subject><subject>Hospitals</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Industrialized nations</subject><subject>Laboratories</subject><subject>Laboratory tests</subject><subject>Leukocyte Count</subject><subject>Lipids</subject><subject>Male</subject><subject>Males</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Nigeria</subject><subject>Physical Sciences</subject><subject>Platelets</subject><subject>Population</subject><subject>Potassium</subject><subject>Pregnancy</subject><subject>Pregnant women</subject><subject>Reference Values</subject><subject>Research and Analysis Methods</subject><subject>Rural areas</subject><subject>Sex differences</subject><subject>Sex Factors</subject><subject>Sexually transmitted diseases</subject><subject>Sodium</subject><subject>STD</subject><subject>Studies</subject><subject>Syphilis</subject><subject>Syphilis - blood</subject><subject>Urea</subject><subject>Virology</subject><subject>Young Adult</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNqNk01v1DAQhiMEoqXwDxBEQkJw2MVfceILUlXxUamiEl9Xa2JPsqkce7GTir3w2_G226qLekA5ZDR-5h37taconlOypLym7y7CHD245Tp4XBKiuKLqQXFIFWcLyQh_eCc-KJ6kdEFIxRspHxcHTDScUVYfFn9OwriOuEKfhkssI3YY0Zscge8xlV2I5QpHmIIL_aYEb0vjBj8YcKXJC0Oa4qZ00IaYmRyuIcKIE8ZUWoxZ05ZdDGPpQxxzzZehz1nwJdjZTelp8agDl_DZ7n9U_Pj44fvJ58XZ-afTk-OzhZGKTYtKcs4FckItJVIJZSuFykgUbdWipMpCQ0SdQ6KACctqqlDKriK2lcYwflS8vNZdu5D0zrqkaZWdqCWjNBOn14QNcKHXcRghbnSAQV8lQuw1xGkwDnWrag65makrEFUDjWWylm2jFBGEdjJrvd91m9sRrUE_RXB7ovsrfljpPlxqQRgTimeBNzuBGH7NmCadjTboHHgM89W-q7qmNRUZffUPev_pdlQP-QCD70Lua7ai-ljQpmKKyW3b5T1U_my-aJPfWTfk_F7B272CzEz4e-phTkmffvv6_-z5z3329R12heCmVQpunobg0z4orkETQ0r59d6aTInejsmNG3o7Jno3Jrnsxd0Lui26mQv-F_oeDqs</recordid><startdate>20140515</startdate><enddate>20140515</enddate><creator>Miri-Dashe, Timzing</creator><creator>Osawe, Sophia</creator><creator>Tokdung, Monday</creator><creator>Daniel, Monday Tokdung Nenbammun</creator><creator>Daniel, Nenbammun</creator><creator>Choji, Rahila Pam</creator><creator>Mamman, Ille</creator><creator>Deme, Kurt</creator><creator>Damulak, Dapus</creator><creator>Abimiku, Alash'le</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20140515</creationdate><title>Comprehensive reference ranges for hematology and clinical chemistry laboratory parameters derived from normal Nigerian adults</title><author>Miri-Dashe, Timzing ; Osawe, Sophia ; Tokdung, Monday ; Daniel, Monday Tokdung Nenbammun ; Daniel, Nenbammun ; Choji, Rahila Pam ; Mamman, Ille ; Deme, Kurt ; Damulak, Dapus ; Abimiku, Alash'le</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-563334e301d106949d59e9c6e4b5be619da8047be609a24d2719e66f50db6cc23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Adults</topic><topic>Aged</topic><topic>Bicarbonates</topic><topic>Bilirubin</topic><topic>Biochemistry</topic><topic>Biology and Life Sciences</topic><topic>Blood</topic><topic>Blood & organ donations</topic><topic>Blood cells</topic><topic>Blood donation</topic><topic>Blood Donors</topic><topic>Blood transfusions</topic><topic>Carbonates</topic><topic>Chemistry</topic><topic>Chemistry, Clinical - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Miri-Dashe, Timzing</au><au>Osawe, Sophia</au><au>Tokdung, Monday</au><au>Daniel, Monday Tokdung Nenbammun</au><au>Daniel, Nenbammun</au><au>Choji, Rahila Pam</au><au>Mamman, Ille</au><au>Deme, Kurt</au><au>Damulak, Dapus</au><au>Abimiku, Alash'le</au><au>Hartshorn, Kevan L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comprehensive reference ranges for hematology and clinical chemistry laboratory parameters derived from normal Nigerian adults</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2014-05-15</date><risdate>2014</risdate><volume>9</volume><issue>5</issue><spage>e93919</spage><epage>e93919</epage><pages>e93919-e93919</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Interpretation of laboratory test results with appropriate diagnostic accuracy requires reference or cutoff values. This study is a comprehensive determination of reference values for hematology and clinical chemistry in apparently healthy voluntary non-remunerated blood donors and pregnant women.
Consented clients were clinically screened and counseled before testing for HIV, Hepatitis B, Hepatitis C and Syphilis. Standard national blood donors' questionnaire was administered to consented blood donors. Blood from qualified volunteers was used for measurement of complete hematology and chemistry parameters. Blood samples were analyzed from a total of 383 participants, 124 (32.4%) males, 125 (32.6%) non-pregnant females and 134 pregnant females (35.2%) with a mean age of 31 years. Our results showed that the red blood cells count (RBC), Hemoglobin (HB) and Hematocrit (HCT) had significant gender difference (p = 0.000) but not for total white blood count (p>0.05) which was only significantly higher in pregnant verses non-pregnant women (p = 0.000). Hemoglobin and Hematocrit values were lower in pregnancy (P = 0.000). Platelets were significantly higher in females than men (p = 0.001) but lower in pregnant women (p = .001) with marked difference in gestational period. For clinical chemistry parameters, there was no significant difference for sodium, potassium and chloride (p>0.05) but gender difference exists for Bicarbonate (HCO3), Urea nitrogen, Creatinine as well as the lipids (p<0.05). Total bilirubin was significantly higher in males than females (p = 0.000). Significant differences exist for all chemistry parameters between pregnant and non-pregnant women in this study (p<0.05), except Amylase and total cholesterol (p>0.05).
Hematological and Clinical Chemistry reference ranges established in this study showed significant gender differences. Pregnant women also differed from non-pregnant females and during pregnancy. This is the first of such comprehensive study to establish reference values among adult Nigerians and difference observed underscore the need to establish reference values for different populations.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24832127</pmid><doi>10.1371/journal.pone.0093919</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2014-05, Vol.9 (5), p.e93919-e93919 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1524876211 |
| source | Access via ProQuest (Open Access); PubMed Central |
| subjects | Adolescent Adult Adults Aged Bicarbonates Bilirubin Biochemistry Biology and Life Sciences Blood Blood & organ donations Blood cells Blood donation Blood Donors Blood transfusions Carbonates Chemistry Chemistry, Clinical - standards Cholesterol Clients Creatinine Cross-Sectional Studies Diagnostic systems Erythrocyte Count Erythrocytes Female Females Gender aspects Hematocrit Hematologic Tests - methods Hematology Hematology - standards Hemoglobin Hemoglobins Hepatitis Hepatitis B Hepatitis B - blood Hepatitis C Hepatitis C - blood HIV HIV Infections - blood HIV tests Hospitals Human immunodeficiency virus Humans Industrialized nations Laboratories Laboratory tests Leukocyte Count Lipids Male Males Medicine and Health Sciences Middle Aged Nigeria Physical Sciences Platelets Population Potassium Pregnancy Pregnant women Reference Values Research and Analysis Methods Rural areas Sex differences Sex Factors Sexually transmitted diseases Sodium STD Studies Syphilis Syphilis - blood Urea Virology Young Adult |
| title | Comprehensive reference ranges for hematology and clinical chemistry laboratory parameters derived from normal Nigerian adults |
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