MAF1 sequesters mitochondria for Toxoplasma gondii

  MAF1 also altered host cells' response to parasite infection; murine monocytes growing in cell culture secreted a different constellation of immunomodulatory proteins when infected with MAF1-expressing type II versus wild-type type II parasites. [...]in mice infected with parasites, the prese...

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Bibliographic Details
Published in:PLoS biology 2014-04, Vol.12 (4), p.e1001846-e1001846
Main Author: Sedwick, Caitlin
Format: Article
Language:English
Subjects:
Animals
Biology
Biology and Life Sciences
Female
Genetic engineering
Genomes
Immune system
Mitochondria
Mitochondria - parasitology
Parasites
Proteins
Protozoa
Protozoan Proteins - immunology
Toxoplasma - immunology
Toxoplasma - pathogenicity
Toxoplasmosis - immunology
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Summary:  MAF1 also altered host cells' response to parasite infection; murine monocytes growing in cell culture secreted a different constellation of immunomodulatory proteins when infected with MAF1-expressing type II versus wild-type type II parasites. [...]in mice infected with parasites, the presence or absence of MAF1 affected both the host animals' immune responses and the patterns of genes they expressed in response to infection.
ISSN:1545-7885
1544-9173
1545-7885
DOI:10.1371/journal.pbio.1001846