Contribution of intestinal barrier damage, microbial translocation and HIV-1 infection status to an inflammaging signature

• Published in: PloS one 2014-05, Vol.9 (5), p.e97171-e97171
• Main Authors: Steele, Amanda K, Lee, Eric J, Vestal, Brian, Hecht, Daniel, Dong, Zachary, Rapaport, Eric, Koeppe, John, Campbell, Thomas B, Wilson, Cara C
• Format: Article
• Language: English
• Subjects: Acquired immune deficiency syndrome; Activation; Adolescent; Adult; Adults; Age; Aging; AIDS; Analysis; Bacteria - metabolism; Biology and life sciences; Biomarkers; Biomarkers - blood; Cardiovascular disease; Cardiovascular diseases; Cell activation; Cluster analysis; Clustering; Cytomegalovirus; Gene Expression Regulation; Geriatrics; Health aspects; Health risks; HIV; HIV Infections - blood; HIV Infections - complications; HIV-1 - physiology; Human immunodeficiency virus; Humans; Immune response; Infections; Inflammation; Inflammation - complications; Inflammation - immunology; Inflammation - microbiology; Inflammation - virology; Interleukin 6; Intestinal Mucosa - microbiology; Intestinal Mucosa - pathology; Intestine; Lipopolysaccharides; Lymphocytes T; Male; Medicine and Health Sciences; Microorganisms; Middle Aged; Movement; Older people; Phenotype; Risk; T cells; Translocation; Young Adult
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0097171

Systemic inflammation is a characteristic of both HIV-1 infection and aging ("inflammaging"). Intestinal epithelial barrier damage (IEBD) and microbial translocation (MT) contribute to HIV-associated inflammation, but their impact on inflammaging remains unclear. Plasma biomarkers for IEBD (iFABP), MT (LPS, sCD14), T-cell activation (sCD27), and inflammation (hsCRP, IL-6) were measured in 88 HIV-1 uninfected (HIV(neg)) and 83 treated, HIV-1-infected (HIV(pos)) adults from 20-100 years old. Age positively correlated with iFABP (r = 0.284, p = 0.008), sCD14 (r = 0.646, p =