A panel of serum biomarkers differentiates IgA nephropathy from other renal diseases

There is increasing evidence that galactose-deficient IgA1 (Gd-IgA1) and Gd-IgA1-containing immune complexes are important for the pathogenesis of IgA nephropathy (IgAN). In the present study, we assessed a novel noninvasive multi-biomarker approach in the diagnostic test for IgAN. We compared serum...

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Bibliographic Details
Published in:PloS one 2014-05, Vol.9 (5), p.e98081
Main Authors: Yanagawa, Hiroyuki, Suzuki, Hitoshi, Suzuki, Yusuke, Kiryluk, Krzysztof, Gharavi, Ali G, Matsuoka, Kiyoshi, Makita, Yuko, Julian, Bruce A, Novak, Jan, Tomino, Yasuhiko
Format: Article
Language:English
Subjects:
Adult
Antibodies
Antigen-antibody complexes
Autoimmune diseases
Biological markers
Biology and Life Sciences
Biomarkers
Biomarkers - blood
Biopsy
Chronic kidney failure
Comparative analysis
Cross-Sectional Studies
Diagnosis
Diagnosis, Differential
Diagnostic systems
Disease control
Diseases
Female
Gadolinium
Galactose
Galactose - metabolism
Glomerulonephritis, IGA - blood
Glomerulonephritis, IGA - diagnosis
Humans
IgA nephropathy
Immunoglobulin A
Immunoglobulin A - blood
Immunoglobulin A - metabolism
Immunoglobulin G
Immunoglobulin G - blood
Immunoglobulins
Internal medicine
Isotypes
Kidney diseases
Kidneys
Lupus
Lupus nephritis
Male
Medicine
Medicine and Health Sciences
Middle Aged
Nephritis
Nephrology
Pathogenesis
Patients
Proteins
Proteinuria
Rodents
Serum levels
Studies
Surgeons
University faculty
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Summary:There is increasing evidence that galactose-deficient IgA1 (Gd-IgA1) and Gd-IgA1-containing immune complexes are important for the pathogenesis of IgA nephropathy (IgAN). In the present study, we assessed a novel noninvasive multi-biomarker approach in the diagnostic test for IgAN. We compared serum levels of IgA, IgG, Gd-IgA1, Gd-IgA1-specific IgG and Gd-IgA1-specific IgA in 135 IgAN patients, 79 patients with non-IgAN chronic kidney disease (CKD) controls and 106 healthy controls. Serum was collected at the time of kidney biopsy from all IgAN and CKD patients. Each serum marker was significantly elevated in IgAN patients compared to CKD (P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0098081