Prognostic significance of CD26 in patients with colorectal cancer

CD26, dipeptidyl peptidase IV, was discovered firstly as a membrane-associated peptidase on the surface of leukocyte. We previously demonstrated that a subpopulation of CD26+ cells were associated with the development of distant metastasis, enhanced invasiveness and chemoresistance in colorectal can...

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Bibliographic Details
Published in:PloS one 2014-05, Vol.9 (5), p.e98582-e98582
Main Authors: Lam, Colin Siu-Chi, Cheung, Alvin Ho-Kwan, Wong, Sunny Kit-Man, Wan, Timothy Ming-Hun, Ng, Lui, Chow, Ariel Ka-Man, Cheng, Nathan Shiu-Man, Pak, Ryan Chung-Hei, Li, Hung-Sing, Man, Johnny Hon-Wai, Yau, Thomas Chung-Cheung, Lo, Oswens Siu-Hung, Poon, Jensen Tung-Chung, Pang, Roberta Wen-Chi, Law, Wai Lun
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Analysis
Antigens
Biology and Life Sciences
Cancer
Cancer patients
Care and treatment
Chemoresistance
Collagen
Colorectal cancer
Colorectal carcinoma
Colorectal Neoplasms - diagnosis
Colorectal Neoplasms - metabolism
Cyclin-dependent kinases
Development and progression
Dipeptidyl Peptidase 4 - metabolism
Dipeptidyl-peptidase IV
Extracellular matrix
Female
Formaldehyde
Gene Expression Regulation, Neoplastic - genetics
Gene Expression Regulation, Neoplastic - physiology
Humans
Immunohistochemistry
Invasiveness
Kaplan-Meier Estimate
Kinases
Leukocytes
Levels
Male
Medical diagnosis
Medical prognosis
Medical research
Medical screening
Medicine
Medicine and Health Sciences
Metastases
Metastasis
Middle Aged
Neoplasm Metastasis - diagnosis
Neoplasm Staging
Oncology
Paraffin
Patients
Peptidase
Prognosis
Proteins
Rapid prototyping
Surgery
Tissues
Tumors
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Summary:CD26, dipeptidyl peptidase IV, was discovered firstly as a membrane-associated peptidase on the surface of leukocyte. We previously demonstrated that a subpopulation of CD26+ cells were associated with the development of distant metastasis, enhanced invasiveness and chemoresistance in colorectal cancer (CRC). In order to understand the clinical impact of CD26, the expression was investigated in CRC patient's specimens. This study investigated the prognostic significance of tumour CD26 expression in patients with CRC. Examination of CD26+ cells has significant clinical impact for the prediction of distant metastasis development in colorectal cancer, and could be used as a selection criterion for further therapy. Tumour CD26 expression levels were studied by immunohistochemistry using Formalin-fixed paraffin embedded (FFPE) tissues in 143 patients with CRC. Tumour CD26 expression levels were correlated with clinicopathological features of the CRC patients. The prognostic significance of tumour tissue CD26 expression levels was assessed by univariate and multivariate analyses. CD26 expression levels in CRC patients with distant metastasis were significantly higher than those in non-metastatic. High expression levels of CD26 were significantly associated with advanced tumour staging. Patients with a high CD26 expression level had significantly worse overall survival than those with a lower level (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0098582