Trajectories in glycemic control over time are associated with cognitive performance in elderly subjects with type 2 diabetes

To study the relationships of long-term trajectories of glycemic control with cognitive performance in cognitively normal elderly with type 2 diabetes (T2D). Subjects (n = 835) pertain to a diabetes registry (DR) established in 1998 with an average of 18 HbA1c measurements per subject, permitting id...

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Published in:PloS one 2014-06, Vol.9 (6), p.e97384-e97384
Main Authors: Ravona-Springer, Ramit, Heymann, Anthony, Schmeidler, James, Moshier, Erin, Godbold, James, Sano, Mary, Leroith, Derek, Johnson, Sterling, Preiss, Rachel, Koifman, Keren, Hoffman, Hadas, Silverman, Jeremy M, Beeri, Michal Schnaider
Format: Article
Language:English
Subjects:
Aged
Biology and Life Sciences
Blood pressure
Chronic illnesses
Classification
Cognition
Cognitive ability
Comparative analysis
Consortia
Covariance
Dementia
Diabetes
Diabetes mellitus
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - physiopathology
Diabetes therapy
Direct reduction
Executive function
Female
Geriatrics
Glucose
Glycated Hemoglobin A - metabolism
Health services
Hemoglobin
Humans
Hyperglycemia
Israel
Male
Medical screening
Medicine and Health Sciences
Memory
Mental depression
Mortality
Older people
Preventive medicine
Psychiatry
Registries
Short term memory
Systematic review
Time Factors
Trajectory analysis
Trajectory control
Trends
Type 2 diabetes
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Summary:To study the relationships of long-term trajectories of glycemic control with cognitive performance in cognitively normal elderly with type 2 diabetes (T2D). Subjects (n = 835) pertain to a diabetes registry (DR) established in 1998 with an average of 18 HbA1c measurements per subject, permitting identification of distinctive trajectory groups of HbA1c and examining their association with cognitive function in five domains: episodic memory, semantic categorization, attention/working memory, executive function, and overall cognition. Analyses of covariance compared cognitive function among the trajectory groups adjusting for sociodemographic, cardiovascular, diabetes-related covariates and depression. Subjects averaged 72.8 years of age. Six trajectories of HbA1c were identified, characterized by HbA1c level at entry into the DR (Higher/Lower), and trend over time (Stable/Decreasing/Increasing). Both groups with a trajectory of decreasing HbA1c levels had high HbA1c levels at entry into the DR (9.2%, 10.7%), and high, though decreasing, HbA1c levels over time. They had the worst cognitive performance, particularly in overall cognition (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0097384