Prognostic value of MET gene copy number and protein expression in patients with surgically resected non-small cell lung cancer: a meta-analysis of published literatures

The prognostic value of the copy number (GCN) and protein expression of the mesenchymal-epithelial transition (MET) gene for survival of patients with non-small cell lung cancer (NSCLC) remains controversial. This study aims to comprehensively and quantitatively asses the suitability of MET GCN and...

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Bibliographic Details
Published in:PloS one 2014-06, Vol.9 (6), p.e99399-e99399
Main Authors: Guo, Baoping, Cen, Hong, Tan, Xiaohong, Liu, Wenjian, Ke, Qing
Format: Article
Language:English
Subjects:
Adenocarcinoma
Adult
Aged
Aged, 80 and over
Analysis
Biology and Life Sciences
Cancer
Carcinoma, Non-Small-Cell Lung - genetics
Carcinoma, Non-Small-Cell Lung - pathology
Carcinoma, Non-Small-Cell Lung - surgery
Care and treatment
Cell survival
Chemotherapy
Clinical trials
Confidence intervals
Copy number
Epithelial-Mesenchymal Transition - genetics
Female
Gene Dosage
Gene expression
Genes
Growth factors
Histology
Humans
Immunohistochemistry
Kinases
Low level
Lung cancer
Lung diseases
Lung Neoplasms - genetics
Lung Neoplasms - surgery
Male
Medical prognosis
Medical research
Medicine and Health Sciences
Mesenchyme
MET protein
Meta-analysis
Methods
Middle Aged
Multivariate analysis
Non-small cell lung cancer
Non-small cell lung carcinoma
Patients
Prognosis
Protein expression
Proteins
Proto-Oncogene Proteins c-met - genetics
Publication Bias
Quality
Scientific papers
Search engines
Sensitivity analysis
Small cell lung cancer
Stem cells
Studies
Survival
Survival Analysis
Citations: Items that this one cites
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Description
Summary:The prognostic value of the copy number (GCN) and protein expression of the mesenchymal-epithelial transition (MET) gene for survival of patients with non-small cell lung cancer (NSCLC) remains controversial. This study aims to comprehensively and quantitatively asses the suitability of MET GCN and protein expression to predict patients' survival. PubMed, Embase, Web of Science and Google Scholar were searched for articles comparing overall survival in patients with high MET GCN or protein expression with those with low level. Pooled hazard ratio (HR) and 95% confidence intervals (CIs) were calculated using the random and the fixed-effects models. Subgroup and sensitivity analyses were also performed. Eighteen eligible studies enrolling 5,516 patients were identified. Pooled analyses revealed that high MET GCN or protein expression was associated with poor overall survival (OS) (GCN: HR = 1.90, 95% CI 1.35-2.68, p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0099399