The changing geometry of a fitness landscape along an adaptive walk

It has recently been noted that the relative prevalence of the various kinds of epistasis varies along an adaptive walk. This has been explained as a result of mean regression in NK model fitness landscapes. Here we show that this phenomenon occurs quite generally in fitness landscapes. We propose a...

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Bibliographic Details
Published in:PLoS computational biology 2014-05, Vol.10 (5), p.e1003520-e1003520
Main Authors: Greene, Devin, Crona, Kristina
Format: Article
Language:English
Subjects:
Adaptation, Physiological - genetics
Animals
Biology and Life Sciences
Computer Simulation
Confidence intervals
Epistasis, Genetic - genetics
Evolution, Molecular
Genetic Fitness - genetics
Genetics, Population
Genotype & phenotype
Geometry
Graphs
Human mechanics
Humans
Models, Genetic
Models, Statistical
Mutation
Physical Sciences
Physiological research
Programming languages
Selection, Genetic - genetics
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Summary:It has recently been noted that the relative prevalence of the various kinds of epistasis varies along an adaptive walk. This has been explained as a result of mean regression in NK model fitness landscapes. Here we show that this phenomenon occurs quite generally in fitness landscapes. We propose a simple and general explanation for this phenomenon, confirming the role of mean regression. We provide support for this explanation with simulations, and discuss the empirical relevance of our findings.
ISSN:1553-7358
1553-734X
1553-7358
DOI:10.1371/journal.pcbi.1003520