Medulloblastoma in China: clinicopathologic analyses of SHH, WNT, and non-SHH/WNT molecular subgroups reveal different therapeutic responses to adjuvant chemotherapy

Medulloblastoma (MB) is one of the most common primary central nervous system tumors in children. Data is lacking of a large cohort of medulloblastoma patients in China. Also, our knowledge on the sensitivity of different molecular subgroups of MB to adjuvant radiation therapy (RT) or chemotherapy (...

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Bibliographic Details
Published in:PloS one 2014-06, Vol.9 (6), p.e99490-e99490
Main Authors: Zhang, Zhen-Yu, Xu, Jian, Ren, Yong, Li, Kay Ka-Wai, Ng, Ho-Keung, Mao, Ying, Zhong, Ping, Yao, Yu, Zhou, Liang-Fu
Format: Article
Language:English
Subjects:
Adaptor Proteins, Signal Transducing - analysis
Adjuvant chemotherapy
Adolescent
Adult
Adults
Age
Analysis
Antigens
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
beta Catenin - analysis
Cancer therapies
Central nervous system
Cerebellar Neoplasms - classification
Cerebellar Neoplasms - drug therapy
Cerebellar Neoplasms - genetics
Cerebellar Neoplasms - pathology
Cerebellar Neoplasms - therapy
Chemotherapy
Chemotherapy, Adjuvant
Child
Child, Preschool
Children
Children & youth
China
Combined Modality Therapy
Cranial Irradiation
Craniotomy
Disease-Free Survival
Ethics
Female
Females
Gene expression
Health aspects
Hedgehog protein
Hedgehog Proteins - genetics
Hospitals
Humans
Male
Males
Medical prognosis
Medicine and Health Sciences
Medulloblastoma
Medulloblastoma - classification
Medulloblastoma - drug therapy
Medulloblastoma - genetics
Medulloblastoma - pathology
Medulloblastoma - therapy
Middle Aged
Multivariate analysis
Neoplasm Proteins - analysis
Neoplasm Proteins - genetics
Nervous system
Neurosurgery
Paraffin
Pathology
Patients
Prognosis
Proportional Hazards Models
Radiation
Radiation therapy
Radiotherapy, Adjuvant
Subgroups
Survival
Tissues
Tumors
Wnt protein
Wnt Proteins - genetics
Wnt Signaling Pathway
Young Adult
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Summary:Medulloblastoma (MB) is one of the most common primary central nervous system tumors in children. Data is lacking of a large cohort of medulloblastoma patients in China. Also, our knowledge on the sensitivity of different molecular subgroups of MB to adjuvant radiation therapy (RT) or chemotherapy (CHT) is still limited. The authors performed a retrospective study of 173 medulloblastoma patients treated at two institutions from 2002 to 2011. Formalin-fixed paraffin embedded (FFPE) tissues were available in all the cases and sections were stained to classify histological and molecular subgroups. Univariate and multivariate analyses were used to investigate prognostic factors. Of 173 patients, there were 118 children and 55 adults, 112 males and 61 females. Estimated 5-year overall survival (OS) rates for all patients, children and adults were 52%, 48% and 63%, respectively. After multivariate analysis, postoperative primary radiation therapy (RT) and chemotherapy (CHT) were revealed as favorable prognostic factors influencing OS and EFS. Postoperative primary chemotherapy (CHT) was found significantly improving the survival of children (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0099490