Transcriptome profiling of the theca interna from bovine ovarian follicles during atresia

The theca interna is a specialized stromal layer that envelops each growing ovarian follicle. It contains capillaries, fibroblasts, immune cells and the steroidogenic cells that synthesize androgens for conversion to estradiol by the neighboring granulosa cells. During reproductive life only a small...

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Bibliographic Details
Published in:PloS one 2014-06, Vol.9 (6), p.e99706-e99706
Main Authors: Hatzirodos, Nicholas, Irving-Rodgers, Helen F, Hummitzsch, Katja, Rodgers, Raymond J
Format: Article
Language:English
Subjects:
17β-Estradiol
Androgens
Animals
Apoptosis
Biology and Life Sciences
Cancer
Capillaries
Cattle
Cell cycle
Cell death
Cellular stress response
Clustering
Cytokines
Deoxyribonucleic acid
Discipline
DNA
DNA biosynthesis
DNA replication
Female
Fibroblasts
Follicles
Follicular Atresia - metabolism
Gene expression
Gene Expression Profiling
Gene regulation
Genes
Granulosa cells
Growth factors
Gynecology
Hepatocyte growth factor
Hormones
Immune system
Macrophages
Medicine and Health Sciences
Obstetrics
p53 Protein
Phagocytosis
Proteins
Receptors
Regression analysis
Replication
Reproductive health
Retina
Retinoblastoma
Sex hormones
Software
Theca
Theca Cells - cytology
Theca Cells - metabolism
Transcriptome - physiology
Transforming growth factor-b1
Tumor proteins
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Description
Summary:The theca interna is a specialized stromal layer that envelops each growing ovarian follicle. It contains capillaries, fibroblasts, immune cells and the steroidogenic cells that synthesize androgens for conversion to estradiol by the neighboring granulosa cells. During reproductive life only a small number of follicles will grow to a sufficient size to ovulate, whereas the majority of follicles will undergo regression/atresia and phagocytosis by macrophages. To identify genes which are differentially regulated in the theca interna during follicular atresia, we undertook transcriptome profiling of the theca interna from healthy (n = 10) and antral atretic (n = 5) bovine follicles at early antral stages (
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0099706