Association between RANTES gene polymorphisms and asthma: a meta-analysis

A few recent studies have suggested that regulated on activation, normal T cell expressed and secreted (RANTES) polymorphisms (-403 G/A, -28C/G) are associated with asthma. However, there still existed studies which did not confirm these correlations. The objective of this study was to evaluate the...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2014-06, Vol.9 (6), p.e90460-e90460
Main Authors: Wen, Dan, Du, Xin, Nie, Shao-Ping, Dong, Jian-Zeng, Ma, Chang-Sheng
Format: Article
Language:English
Subjects:
Airway management
Analysis
Asthma
Asthma - genetics
Biology and Life Sciences
Cardiology
Cell activation
Cell adhesion & migration
Chemokine CCL5 - chemistry
Chemokine CCL5 - genetics
Chemokines
Confidence intervals
Cytokines
Genes
Genetic aspects
Genetic Association Studies
Genetic polymorphisms
Genotype
Humans
Lymphocytes T
Medical ethics
Medicine and Health Sciences
Meta-analysis
Odds Ratio
Physical Sciences
Polymorphism
Polymorphism, Genetic
RANTES
Research and Analysis Methods
Risk factors
Studies
T cells
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A few recent studies have suggested that regulated on activation, normal T cell expressed and secreted (RANTES) polymorphisms (-403 G/A, -28C/G) are associated with asthma. However, there still existed studies which did not confirm these correlations. The objective of this study was to evaluate the relationship of RANTES and asthma using a meta-analysis. Pubmed, Embase, and Cochrane library databases were systemically searched. Data were extracted by two independent reviewers and pooled odds ratio (OR) with 95% confidence interval (CI) were calculated. Eighteen studies were enrolled, including a total of 2558 cases and 2630 controls of -403 G/A, as well as 3311 cases and 4031 controls of -28C/G in this meta-analysis. The overall ORs and 95% CIs of -403 G/A were 1.19, 1.06-1.33 (P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0090460