Association between RANTES gene polymorphisms and asthma: a meta-analysis

A few recent studies have suggested that regulated on activation, normal T cell expressed and secreted (RANTES) polymorphisms (-403 G/A, -28C/G) are associated with asthma. However, there still existed studies which did not confirm these correlations. The objective of this study was to evaluate the...

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Published in:PloS one 2014-06, Vol.9 (6), p.e90460-e90460
Main Authors: Wen, Dan, Du, Xin, Nie, Shao-Ping, Dong, Jian-Zeng, Ma, Chang-Sheng
Format: Article
Language:English
Subjects:
Airway management
Analysis
Asthma
Asthma - genetics
Biology and Life Sciences
Cardiology
Cell activation
Cell adhesion & migration
Chemokine CCL5 - chemistry
Chemokine CCL5 - genetics
Chemokines
Confidence intervals
Cytokines
Genes
Genetic aspects
Genetic Association Studies
Genetic polymorphisms
Genotype
Humans
Lymphocytes T
Medical ethics
Medicine and Health Sciences
Meta-analysis
Odds Ratio
Physical Sciences
Polymorphism
Polymorphism, Genetic
RANTES
Research and Analysis Methods
Risk factors
Studies
T cells
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description A few recent studies have suggested that regulated on activation, normal T cell expressed and secreted (RANTES) polymorphisms (-403 G/A, -28C/G) are associated with asthma. However, there still existed studies which did not confirm these correlations. The objective of this study was to evaluate the relationship of RANTES and asthma using a meta-analysis. Pubmed, Embase, and Cochrane library databases were systemically searched. Data were extracted by two independent reviewers and pooled odds ratio (OR) with 95% confidence interval (CI) were calculated. Eighteen studies were enrolled, including a total of 2558 cases and 2630 controls of -403 G/A, as well as 3311 cases and 4031 controls of -28C/G in this meta-analysis. The overall ORs and 95% CIs of -403 G/A were 1.19, 1.06-1.33 (P
doi_str_mv 10.1371/journal.pone.0090460
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This meta-analysis showed that RANTES -403 G/A polymorphism was a risk factor for asthma, while -28C/G polymorphism were not associated with asthma.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24963658</pmid><doi>10.1371/journal.pone.0090460</doi><oa>free_for_read</oa></addata></record>
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subjects Airway management
Analysis
Asthma
Asthma - genetics
Biology and Life Sciences
Cardiology
Cell activation
Cell adhesion & migration
Chemokine CCL5 - chemistry
Chemokine CCL5 - genetics
Chemokines
Confidence intervals
Cytokines
Genes
Genetic aspects
Genetic Association Studies
Genetic polymorphisms
Genotype
Humans
Lymphocytes T
Medical ethics
Medicine and Health Sciences
Meta-analysis
Odds Ratio
Physical Sciences
Polymorphism
Polymorphism, Genetic
RANTES
Research and Analysis Methods
Risk factors
Studies
T cells
title Association between RANTES gene polymorphisms and asthma: a meta-analysis
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