Cortical thinning in temporo-parietal junction (TPJ) in non-affective first-episode of psychosis patients with persistent negative symptoms

Negative symptoms represent an unmet therapeutic need in many patients with schizophrenia. In an extension to our previous voxel-based morphometry findings, we employed a more specific, vertex-based approach to explore cortical thinning in relation to persistent negative symptoms (PNS) in non-affect...

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Bibliographic Details
Published in:PloS one 2014-06, Vol.9 (6), p.e101372-e101372
Main Authors: Bodnar, Michael, Hovington, Cindy L, Buchy, Lisa, Malla, Ashok K, Joober, Ridha, Lepage, Martin
Format: Article
Language:English
Subjects:
Adolescent
Adult
Antipsychotics
Biology and Life Sciences
Brain
Cognitive ability
Cortex
Cortex (cingulate)
Cortex (frontal)
Cortex (parietal)
Cortex (temporal)
Development and progression
Early intervention
Emotional behavior
Etiology
Female
Frontal gyrus
Health aspects
Humans
Illnesses
Magnetic Resonance Imaging
Male
Medical imaging
Medicine and Health Sciences
Mental disorders
Mental health
Morphometry
Neurology
Neurosurgery
Parahippocampal gyrus
Parietal Lobe - pathology
Parietal Lobe - physiopathology
Patients
Prevention
Psychiatry
Psychosis
Psychotic Disorders - diagnosis
Psychotic Disorders - pathology
Psychotropic drugs
Schizophrenia
Studies
Superior temporal gyrus
Temporal gyrus
Temporal lobe
Temporal Lobe - pathology
Temporal Lobe - physiopathology
Thinning
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Description
Summary:Negative symptoms represent an unmet therapeutic need in many patients with schizophrenia. In an extension to our previous voxel-based morphometry findings, we employed a more specific, vertex-based approach to explore cortical thinning in relation to persistent negative symptoms (PNS) in non-affective first-episode of psychosis (FEP) patients to advance our understanding of the pathophysiology of primary negative symptoms. This study included 62 non-affective FEP patients and 60 non-clinical controls; 16 patients were identified with PNS (i.e., at least 1 primary negative symptom at moderate or greater severity sustained for at least 6 consecutive months). Using cortical thickness analyses, we explored for differences between PNS and non-PNS patients as well as between each patient group and healthy controls; cut-off threshold was set at p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0101372