Rs964184 (APOA5-A4-C3-A1) is related to elevated plasma triglyceride levels, but not to an increased risk for vascular events in patients with clinically manifest vascular disease

• Published in: PloS one 2014-06, Vol.9 (6), p.e101082-e101082
• Main Authors: van de Woestijne, Anton P, van der Graaf, Yolanda, de Bakker, Paul I W, Asselbergs, Folkert W, Spiering, Wilko, Visseren, Frank L J
• Format: Article
• Language: English
• Subjects: A1 gene; Aged; Alcohol; Alleles; Aneurysms; Apolipoprotein A-I - blood; Apolipoprotein A-I - genetics; Apolipoprotein A-V; Apolipoprotein C-III - blood; Apolipoprotein C-III - genetics; Apolipoproteins; Apolipoproteins A - blood; Apolipoproteins A - genetics; Atherosclerosis; Biology and Life Sciences; Body mass; Body Mass Index; Body size; Cardiology; Cardiovascular disease; Care and treatment; Cholesterol; Cholesterol, HDL - blood; Cholesterol, LDL - blood; Chromosomes; Coronary vessels; Female; Gene Expression; Gene Frequency; Genomes; Health sciences; Heart attacks; Humans; Hypertriglyceridemia; Hypertriglyceridemia - blood; Hypertriglyceridemia - genetics; Hypertriglyceridemia - pathology; Laboratories; Lipids; Male; Medicine; Medicine and Health Sciences; Metabolic syndrome; Metabolic Syndrome - blood; Metabolic Syndrome - genetics; Metabolic Syndrome - pathology; Middle Aged; Multigene Family; Obesity; Obesity - blood; Obesity - genetics; Obesity - pathology; Patients; Plasma; Polymorphism; Polymorphism, Single Nucleotide; Primary care; Prospective Studies; Risk; Single nucleotide polymorphisms; Single-nucleotide polymorphism; Triglycerides; Triglycerides - blood; Vascular diseases; Vascular Diseases - blood; Vascular Diseases - genetics; Vascular Diseases - pathology
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0101082

Single nucleotide polymorphisms in the APOA5-A4-C3-A1 gene complex are associated with elevated plasma triglycerides and elevated vascular risk in healthy populations. In patients with clinically manifest vascular disease, hypertriglyceridemia and metabolic syndrome are frequently present, but the contribution of these single nucleotide polymorphisms to plasma triglycerides, effect modification by obesity and risk of recurrent vascular events is unknown in these patients. Prospective cohort study of 5547 patients with vascular disease. Rs964184 (APOA5-A4-C3-A1 gene complex) was genotyped, and we evaluated the relation with plasma lipid levels, presence of metabolic syndrome and the risk for new vascular events. The minor allele of rs964184 was strongly associated with log plasma triglycerides (β 0.12; 95%CI 0.10-0.15, p = 1.1*10(-19)), and was also associated with 0.03 mmol/L lower high-density lipoprotein-cholesterol (95%CI 0.01-0.04), and 0.14 mmol/L higher non-high-density lipoprotein-cholesterol (95%CI 0.09-0.20). The minor allele frequency increased from 10.9% in patients with plasma triglycerides