Aerobic exercise for Parkinson's disease: a systematic review and meta-analysis of randomized controlled trials

Although some trials assessed the effectiveness of aerobic exercise for Parkinson's disease (PD), the role of aerobic exercise in the management of PD remained controversial. The purpose of this systematic review is to evaluate the evidence about whether aerobic exercise is effective for PD. Se...

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Bibliographic Details
Published in:PloS one 2014-07, Vol.9 (7), p.e100503
Main Authors: Shu, Hai-Feng, Yang, Tao, Yu, Si-Xun, Huang, Hai-Dong, Jiang, Ling-Li, Gu, Jian-Wen, Kuang, Yong-Qin
Format: Article
Language:English
Subjects:
Aerobics
Andorra
Balance
Clinical trials
Confidence intervals
Disease control
Exercise
Exercise Therapy - methods
Female
Fitness equipment
Gait
Health care
Hospitals
Humans
Identification methods
Intervention
Male
Medicine and Health Sciences
Meta-analysis
Movement disorders
Neurodegenerative diseases
Neurogenesis
Neurosurgery
Parkinson Disease - physiopathology
Parkinson Disease - therapy
Parkinson's disease
Patients
Physical fitness
Physical Sciences
Physical therapy
Postural Balance
Quality assessment
Quality of life
Randomization
Research and Analysis Methods
Statistical analysis
Studies
Systematic review
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Summary:Although some trials assessed the effectiveness of aerobic exercise for Parkinson's disease (PD), the role of aerobic exercise in the management of PD remained controversial. The purpose of this systematic review is to evaluate the evidence about whether aerobic exercise is effective for PD. Seven electronic databases, up to December 2013, were searched to identify relevant studies. Two reviewers independently extracted data and assessed methodological quality based on PEDro scale. Standardised mean difference (SMD) and 95% confidence intervals (CI) of random-effects model were calculated. And heterogeneity was assessed based on the I2 statistic. 18 randomized controlled trials (RCTs) with 901 patients were eligible. The aggregated results suggested that aerobic exercise should show superior effects in improving motor actions (SMD, -0.57; 95% CI -0.94 to -0.19; p = 0.003), balance (SMD, 2.02; 95% CI 0.45 to 3.59; p = 0.01), and gait (SMD, 0.33; 95% CI 0.17 to 0.49; p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0100503