The PlA1/A2 polymorphism of glycoprotein IIIa as a risk factor for myocardial infarction: a meta-analysis

The PlA2 polymorphism of glycoprotein IIIa (GPIIIa) has been previously identified as being associated with myocardial infarction (MI), but whether this represents a true association is entirely unclear due to differences in findings from different studies. We performed a meta-analysis to evaluate w...

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Bibliographic Details
Published in:PloS one 2014-07, Vol.9 (7), p.e101518-e101518
Main Authors: Floyd, Christopher N, Mustafa, Agnesa, Ferro, Albert
Format: Article
Language:English
Subjects:
Aged
Alleles
Bias
Cardiovascular disease
Cardiovascular diseases
Female
Genetic analysis
Genetic aspects
Genetic polymorphisms
Glycoproteins
Health risk assessment
Health risks
Heart attack
Humans
Integrin beta3 - genetics
Male
Medical ethics
Medicine and Health Sciences
Meta-analysis
Middle Aged
Myocardial infarction
Myocardial Infarction - epidemiology
Myocardial Infarction - genetics
Phospholipase A2
Polymorphism
Polymorphism, Genetic
Population (statistical)
Population genetics
Population studies
Risk analysis
Risk Factors
Secondary analysis
Statistical analysis
Studies
Subgroups
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Summary:The PlA2 polymorphism of glycoprotein IIIa (GPIIIa) has been previously identified as being associated with myocardial infarction (MI), but whether this represents a true association is entirely unclear due to differences in findings from different studies. We performed a meta-analysis to evaluate whether this polymorphism is a risk factor for MI. Electronic databases (MEDLINE and EMBASE) were searched for all articles evaluating genetic polymorphisms of GPIIIa. For studies where acute coronary events were recorded in association with genetic analysis, pooled odds ratios (ORs) were calculated using fixed-effects and random-effects models. The primary outcome measure was MI, and a secondary analysis was also performed for acute coronary syndromes (ACS) more generally. 57 studies were eligible for statistical analysis and included 17,911 cases and 24,584 controls. Carriage of the PlA2 allele was significantly associated with MI (n = 40,692; OR 1.077, 95% CI 1.024-1.132; p = 0.004) but with significant publication bias (p = 0.040). The degree of association with MI increased with decreasing age of subjects (≤45 years old: n = 9,547; OR 1.205, 95% CI 1.067-1.360; p = 0.003) and with adjustment of data for conventional cardiovascular risk factors (n = 12,001; OR 1.240, 95% CI 1.117-1.376; p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0101518