Atrophic gastritis: a related factor for osteoporosis in elderly women

• Published in: PloS one 2014-07, Vol.9 (7), p.e101852-e101852
• Main Authors: Kim, Hye Won, Kim, Yang-Hyun, Han, Kyungdo, Nam, Ga Eun, Kim, Gwang Seon, Han, Byoung-Duck, Lee, Anna, Ahn, Ji Yong, Ko, Byung Joon
• Format: Article
• Language: English
• Subjects: Acid production; Aged; Aging; Alcoholic beverages; Analysis; Biocompatibility; Blood pressure; Blood vessels; Body mass; Body mass index; Body size; Bone density; Cholesterol; Confidence intervals; Cross-Sectional Studies; Densitometers; Densitometry; Dual energy X-ray absorptiometry; Endoscopy; Energy consumption; Energy measurement; Female; Femur; Fractures; Gastric cancer; Gastric juice; Gastric mucosa; Gastritis; Gastritis, Atrophic - epidemiology; Gastritis, Atrophic - etiology; Gastrointestinal surgery; Geriatrics; Helicobacter pylori; Hospitals; Humans; Kim, Yang; Male; Medical screening; Medicine; Medicine and Health Sciences; Metabolism; Middle Aged; Older people; Osteopenia; Osteoporosis; Osteoporosis - complications; Osteoporosis - epidemiology; Post-menopause; Postmenopausal women; Regression analysis; Risk analysis; Risk Factors; Smoking; Social Sciences; Spine; Spine (lumbar); Statistical analysis; Stomach cancer; Transportation services; Vitamin deficiency; Womens health
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0101852

Osteoporosis poses a great threat to the aging society. Hypochlorhydric or achlorhydric conditions are risk factors for osteoporosis. Atrophic gastritis also decreases gastric acid production; however, the role of atrophic gastritis as a related factor for osteoporosis is unclear. We investigated the relationship between atrophic gastritis and osteoporosis in postmenopausal women over 60 years of age. A total of 401 postmenopausal women were included in this cross-sectional study, which was conducted during their medical check-ups. Bone mineral densitometry was measured using a dual energy X-ray absorptiometry. Atrophic gastritis was defined endoscopically if gastric mucosa in the antrum and the body were found to be atrophied and thinned and submucosal vessels could be well visualized. The proportion of people with atrophic gastritis was higher in the osteoporotic group than in the group without osteoporosis. A linear relationship was observed in the proportion of atrophic gastritis according to the categories of normal, osteopenia, and osteoporosis at the lumbar spine (p for trend = 0.039) and femur (p for trend = 0.001). A multiple logistic regression analysis revealed that the presence of atrophic gastritis was associated with an increased odds of osteoporosis after adjusting for age, body mass index, triglyceride, high-density lipoprotein cholesterol, alcohol consumption, and smoking status (odds ratio 1.89, 95% confidence interval 1.15-3.11). Atrophic gastritis is associated with an increased likelihood of osteoporosis in Korean elderly women.