P wave dispersion and maximum P wave duration are associated with renal outcomes in chronic kidney disease

P wave parameters measured by 12-lead electrocardiogram (ECG) are commonly used as a noninvasive tool to evaluate left atrial enlargement. This study was designed to assess whether P wave parameters were associated with renal outcomes in chronic kidney disease (CKD) patients. This longitudinal study...

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Bibliographic Details
Published in:PloS one 2014-07, Vol.9 (7), p.e101962-e101962
Main Authors: Huang, Jiun-Chi, Wei, Shu-Yi, Chen, Szu-Chia, Chang, Jer-Ming, Hung, Chi-Chih, Su, Ho-Ming, Hwang, Shang-Jyh, Chen, Hung-Chun
Format: Article
Language:English
Subjects:
Aged
Analysis
Blood
Cardiovascular Diseases - diagnosis
Cardiovascular Diseases - physiopathology
Chronic kidney failure
Community colleges
Confidence intervals
Correlation analysis
Diabetes
Diabetic neuropathy
Dialysis
Disease Progression
Echocardiography
EKG
Electrocardiography
Electrocardiography - methods
Enlargement
Epidermal growth factor receptors
Female
Glomerular Filtration Rate
Heart
Heart - physiopathology
Heart rate
Hemodialysis
Hospitals
Humans
Internal medicine
Kidney diseases
Kidneys
Laboratories
Longitudinal Studies
Male
Medicine
Medicine and Health Sciences
Middle Aged
Nephrology
Parameters
Patient outcomes
Patients
Physical Sciences
Prognosis
Regression Analysis
Renal function
Renal Insufficiency, Chronic - pathology
Renal Insufficiency, Chronic - physiopathology
Research and Analysis Methods
Risk factors
Slopes
Statistical analysis
Wave dispersion
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Summary:P wave parameters measured by 12-lead electrocardiogram (ECG) are commonly used as a noninvasive tool to evaluate left atrial enlargement. This study was designed to assess whether P wave parameters were associated with renal outcomes in chronic kidney disease (CKD) patients. This longitudinal study enrolled 439 patients with CKD stages 3-5. Renal end points were defined as the commencement of dialysis or death. Change in renal function was measured using the estimated glomerular filtration rate (eGFR) slope. We measured two ECG P wave parameters corrected for heart rate, i.e., corrected P wave dispersion and corrected maximum P wave duration. The values of P wave dispersion and maximum P wave duration were 88.8±21.7 ms and 153.3±21.7 ms, respectively. During the follow-up period (mean, 25.2 months), 95 patients (21.6%) started hemodialysis and 30 deaths (6.8%) were recorded. Multivariate Cox regression analysis identified that increased P wave dispersion [hazard ratio (HR), 1.020; 95% confidence interval (CI), 1.009-1.032; P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0101962