Rapid increase of scrub typhus: an epidemiology and spatial-temporal cluster analysis in Guangzhou City, Southern China, 2006-2012

Scrub typhus has been increasingly reported in Southern China, and public health authorities are concerned about its increased incidence. Additionally, little evidence is available on the epidemiology of scrub typhus in Southern China. This study aims to analyze the epidemiological and geographic fe...

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Published in:PloS one 2014-07, Vol.9 (7), p.e101976-e101976
Main Authors: Wei, Yuehong, Huang, Yong, Luo, Lei, Xiao, Xincai, Liu, Lan, Yang, Zhicong
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Analysis
Biology and Life Sciences
Child
Child, Preschool
China - epidemiology
Cluster analysis
Disease control
Disease prevention
Epidemics
Epidemiology
Humans
Incidence
Infant
Infectious diseases
Laboratories
Medicine and Health Sciences
Middle Aged
Orientia tsutsugamushi
Poisson Distribution
Population
Public health
Public Health Surveillance - methods
Risk analysis
Rural areas
Scrub typhus
Scrub Typhus - epidemiology
Sex Factors
Spacetime
Spatial analysis
Spatio-Temporal Analysis
Surveillance
Typhus
Urban areas
Vectors (Biology)
Young Adult
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Huang, Yong
Luo, Lei
Xiao, Xincai
Liu, Lan
Yang, Zhicong
description Scrub typhus has been increasingly reported in Southern China, and public health authorities are concerned about its increased incidence. Additionally, little evidence is available on the epidemiology of scrub typhus in Southern China. This study aims to analyze the epidemiological and geographic features of ST in Guangzhou City, Southern China, to guide the future prevention efforts. Scrub typhus surveillance data in Guangzhou City during 2006-2012 were obtained from the Chinese National Communicable Disease Surveillance Network. We first conducted a descriptive analysis to analyze the epidemiological features of scrub typhus. Then we used space-time scan statistic based on a discrete Poisson model to detect and evaluate high-risk spatial-temporal clusters of scrub typhus. There were 4,001 cases of scrub typhus in Guangzhou City during the study period. The incidence of scrub typhus increased from 3.29 per 100,000 in 2006 to 9.85 per 100,000 in 2012. A summer peak was observed in June and July with a second peak in September and October except year 2009 and 2011. The majority of the cases (71.4%) were among persons aged ≥40 years, and female incidence was higher than male incidence in persons ≥50 years. In the space-time analysis, high-risk clusters were concentrated in rural areas in Guangzhou City. Over the past 7 years, Haizhu District, an urban area, was found to be a high-risk cluster for the first time in 2012. The resurgence of scrub typhus epidemics in Guangzhou population in 2012 necessitates more effective measures for minimizing future epidemics. Consideration of high-risk population and historical spatial-temporal clusters may help prevent scrub typhus. The risk of scrub typhus in urban areas should not be neglected and needs more attention from public health authorities.
doi_str_mv 10.1371/journal.pone.0101976
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Additionally, little evidence is available on the epidemiology of scrub typhus in Southern China. This study aims to analyze the epidemiological and geographic features of ST in Guangzhou City, Southern China, to guide the future prevention efforts. Scrub typhus surveillance data in Guangzhou City during 2006-2012 were obtained from the Chinese National Communicable Disease Surveillance Network. We first conducted a descriptive analysis to analyze the epidemiological features of scrub typhus. Then we used space-time scan statistic based on a discrete Poisson model to detect and evaluate high-risk spatial-temporal clusters of scrub typhus. There were 4,001 cases of scrub typhus in Guangzhou City during the study period. The incidence of scrub typhus increased from 3.29 per 100,000 in 2006 to 9.85 per 100,000 in 2012. A summer peak was observed in June and July with a second peak in September and October except year 2009 and 2011. 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Additionally, little evidence is available on the epidemiology of scrub typhus in Southern China. This study aims to analyze the epidemiological and geographic features of ST in Guangzhou City, Southern China, to guide the future prevention efforts. Scrub typhus surveillance data in Guangzhou City during 2006-2012 were obtained from the Chinese National Communicable Disease Surveillance Network. We first conducted a descriptive analysis to analyze the epidemiological features of scrub typhus. Then we used space-time scan statistic based on a discrete Poisson model to detect and evaluate high-risk spatial-temporal clusters of scrub typhus. There were 4,001 cases of scrub typhus in Guangzhou City during the study period. The incidence of scrub typhus increased from 3.29 per 100,000 in 2006 to 9.85 per 100,000 in 2012. A summer peak was observed in June and July with a second peak in September and October except year 2009 and 2011. The majority of the cases (71.4%) were among persons aged ≥40 years, and female incidence was higher than male incidence in persons ≥50 years. In the space-time analysis, high-risk clusters were concentrated in rural areas in Guangzhou City. Over the past 7 years, Haizhu District, an urban area, was found to be a high-risk cluster for the first time in 2012. The resurgence of scrub typhus epidemics in Guangzhou population in 2012 necessitates more effective measures for minimizing future epidemics. Consideration of high-risk population and historical spatial-temporal clusters may help prevent scrub typhus. The risk of scrub typhus in urban areas should not be neglected and needs more attention from public health authorities.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25006820</pmid><doi>10.1371/journal.pone.0101976</doi><oa>free_for_read</oa></addata></record>
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source Open Access: PubMed Central; Publicly Available Content (ProQuest)
subjects Adolescent
Adult
Aged
Analysis
Biology and Life Sciences
Child
Child, Preschool
China - epidemiology
Cluster analysis
Disease control
Disease prevention
Epidemics
Epidemiology
Humans
Incidence
Infant
Infectious diseases
Laboratories
Medicine and Health Sciences
Middle Aged
Orientia tsutsugamushi
Poisson Distribution
Population
Public health
Public Health Surveillance - methods
Risk analysis
Rural areas
Scrub typhus
Scrub Typhus - epidemiology
Sex Factors
Spacetime
Spatial analysis
Spatio-Temporal Analysis
Surveillance
Typhus
Urban areas
Vectors (Biology)
Young Adult
title Rapid increase of scrub typhus: an epidemiology and spatial-temporal cluster analysis in Guangzhou City, Southern China, 2006-2012
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