Sensitization to food and inhalant allergens in relation to atopic diseases in early childhood: a birth cohort study

A correct interpretation of sensitization to common allergens is critical in determining susceptibility to allergic diseases. The aim of this study was to investigate the patterns of sensitization to food and inhalant allergens, and their relation to the development of atopic diseases in early child...

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Published in:PloS one 2014-07, Vol.9 (7), p.e102809-e102809
Main Authors: Chiu, Chih-Yung, Huang, Yu-Lin, Tsai, Ming-Han, Tu, Yu-Ling, Hua, Man-Chin, Yao, Tsung-Chieh, Yeh, Kuo-Wei, Huang, Jing-Long
Format: Article
Language:English
Subjects:
Administration, Inhalation
Age
Allergens
Allergens - immunology
Allergic diseases
Allergies
Analysis
Asthma
Atopy
Biology and Life Sciences
Child, Preschool
Childhood
Children
Cohort analysis
Cohort Studies
Dermatitis, Atopic - immunology
Development and progression
Diseases
Eczema
Epidemiology
Food
Food allergies
Food hypersensitivity
Food Hypersensitivity - immunology
Health risks
Histamine
Hospitals
Humans
Hypersensitivity, Immediate - immunology
Immunoglobulin E
Immunoglobulin E - immunology
Immunoglobulins
Infant
Medical research
Medicine
Medicine and Health Sciences
Pediatric diseases
Pediatrics
Physicians
Population
Questionnaires
Respiratory diseases
Rheumatology
Rhinitis
Risk factors
Systematic review
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cited_by cdi_FETCH-LOGICAL-c625t-fe5fc8ccb6e51d2c8015ffa14326f60283aa9735a23dbee58ef6df076cce4b43
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creator Chiu, Chih-Yung
Huang, Yu-Lin
Tsai, Ming-Han
Tu, Yu-Ling
Hua, Man-Chin
Yao, Tsung-Chieh
Yeh, Kuo-Wei
Huang, Jing-Long
description A correct interpretation of sensitization to common allergens is critical in determining susceptibility to allergic diseases. The aim of this study was to investigate the patterns of sensitization to food and inhalant allergens, and their relation to the development of atopic diseases in early childhood. Children aged 0 through 4 years from a birth cohort in the Prediction of Allergies in Taiwanese Children (PATCH) study were enrolled. Specific IgE antibody against food and inhalant allergens were measured and their association between total serum IgE levels and atopic diseases were assessed. A total of 182 children were regular followed up at clinics for a four-year follow-up period. The prevalence of food allergen sensitization increased markedly after 6 months of age, reaching up to 47% at 1.5 years of age and then declined significantly to 10% in parallel with a considerable increase in the prevalence of sensitization to inhalant allergens up to 25% at age 4. Food allergen sensitization appeared to be mainly associated with the elevation of serum total IgE levels before age 2. A combined sensitization to food and inhalant allergens had an additive effect on serum IgE levels after age 2, and was significantly associated with the risk of developing atopic diseases at age 4. Sensitization to food occurs early in life, in parallel with the rising prevalence of sensitization to inhalant allergens at older age. A combined sensitization to food and inhalant allergens not only has an additive increase in serum IgE antibody production but also increases the risk of developing allergic respiratory diseases in early childhood.
doi_str_mv 10.1371/journal.pone.0102809
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A combined sensitization to food and inhalant allergens had an additive effect on serum IgE levels after age 2, and was significantly associated with the risk of developing atopic diseases at age 4. Sensitization to food occurs early in life, in parallel with the rising prevalence of sensitization to inhalant allergens at older age. A combined sensitization to food and inhalant allergens not only has an additive increase in serum IgE antibody production but also increases the risk of developing allergic respiratory diseases in early childhood.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25033453</pmid><doi>10.1371/journal.pone.0102809</doi><oa>free_for_read</oa></addata></record>
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identifier ISSN: 1932-6203
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1932-6203
language eng
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subjects Administration, Inhalation
Age
Allergens
Allergens - immunology
Allergic diseases
Allergies
Analysis
Asthma
Atopy
Biology and Life Sciences
Child, Preschool
Childhood
Children
Cohort analysis
Cohort Studies
Dermatitis, Atopic - immunology
Development and progression
Diseases
Eczema
Epidemiology
Food
Food allergies
Food hypersensitivity
Food Hypersensitivity - immunology
Health risks
Histamine
Hospitals
Humans
Hypersensitivity, Immediate - immunology
Immunoglobulin E
Immunoglobulin E - immunology
Immunoglobulins
Infant
Medical research
Medicine
Medicine and Health Sciences
Pediatric diseases
Pediatrics
Physicians
Population
Questionnaires
Respiratory diseases
Rheumatology
Rhinitis
Risk factors
Systematic review
title Sensitization to food and inhalant allergens in relation to atopic diseases in early childhood: a birth cohort study
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