Cardiac energy metabolism and oxidative stress biomarkers in diabetic rat treated with resveratrol

Resveratrol (RSV), polyphenol from grape, was studied to evaluate its effects on calorimetric parameters, energy metabolism, and antioxidants in the myocardium of diabetic rats. The animals were randomly divided into four groups (n = 8): C (control group): normal rats; C-RSV: normal rats receiving R...

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Bibliographic Details
Published in:PloS one 2014-07, Vol.9 (7), p.e102775-e102775
Main Authors: Carolo dos Santos, Klinsmann, Pereira Braga, Camila, Octavio Barbanera, Pedro, Seiva, Fábio Rodrigues Ferreira, Fernandes Junior, Ary, Fernandes, Ana Angélica Henrique
Format: Article
Language:English
Subjects:
Animals
Antioxidants
Antioxidants (Nutrients)
Antioxidants - therapeutic use
Biochemistry
Biological markers
Biology and Life Sciences
Biomarkers
Biomarkers - metabolism
Blood Glucose
Body weight
Calorimetry
Carbon dioxide
Carbonyls
Cardiomyopathy
Cardiovascular disease
Citrate synthase
Dehydrogenase
Dehydrogenases
Diabetes
Diabetes mellitus
Diabetes mellitus (insulin dependent)
Diabetes Mellitus, Experimental - drug therapy
Diabetes Mellitus, Experimental - metabolism
Energy
Energy Intake
Energy Metabolism
Fatty acids
Fatty Acids, Nonesterified - blood
Food intake
Glucose
Glutathione
Glutathione - metabolism
Glutathione reductase
Heart diseases
Homeostasis
Hyperglycemia
Kinases
L-Lactate dehydrogenase
Lactate dehydrogenase
Lactic acid
Male
Metabolism
Musculoskeletal system
Myocardium
Myocardium - metabolism
Oxidation
Oxidative metabolism
Oxidative Stress
Oxygen
Oxygen consumption
Parameters
Pathogenesis
Physiological aspects
Proteins
Pyruvic acid
Rats
Rats, Wistar
Resveratrol
Rodents
Stilbenes - therapeutic use
Streptozocin
Type 1 diabetes
Vanadium oxides
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Summary:Resveratrol (RSV), polyphenol from grape, was studied to evaluate its effects on calorimetric parameters, energy metabolism, and antioxidants in the myocardium of diabetic rats. The animals were randomly divided into four groups (n = 8): C (control group): normal rats; C-RSV: normal rats receiving RSV; DM: diabetic rats; and DM-RSV: diabetics rats receiving RSV. Type 1 diabetes mellitus was induced with administration of streptozotocin (STZ; 60 mg(-1) body weight, single dose, i.p.). After 48 hours of STZ administration, the animals received RSV (1.0 mg/kg/day) for gavage for 30 days. Food, water, and energy intake were higher in the DM group, while administration of RSV caused decreases (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0102775