Diazepam and fluoxetine decrease the stress response in zebrafish

The presence of pharmaceutical products in the aquatic environment has been reported in several studies. However, the impact of these drugs on living organisms is still uncharacterized. Here, we investigated the effects of acute exposure to either diazepam or fluoxetine on the stress response in Dan...

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Bibliographic Details
Published in:PloS one 2014-07, Vol.9 (7), p.e103232
Main Authors: Abreu, Murilo Sander de, Koakoski, Gessi, Ferreira, Daiane, Oliveira, Thiago Acosta, Rosa, João Gabriel Santos da, Gusso, Darlan, Giacomini, Ana Cristina Varrone, Piato, Angelo Luis, Barcellos, Leonardo José Gil
Format: Article
Language:English
Subjects:
Animals
Anti-Anxiety Agents - pharmacology
Antidepressive Agents, Second-Generation - pharmacology
Aquatic ecosystems
Aquatic environment
Biology and Life Sciences
Cortisol
Danio rerio
Diazepam
Diazepam - pharmacology
Drug dosages
Drugs
Enzymes
Female
Fish
Fishes
Fluoxetine
Fluoxetine - pharmacology
Glucocorticoids
Hormones
Hydrocortisone
Inhibition
Male
Medicine and Health Sciences
Psychotropic drugs
Research and Analysis Methods
Stress
Stress response
Stress, Physiological - drug effects
Stresses
Water Pollutants, Chemical - pharmacology
Zebrafish
Zebrafish - physiology
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Summary:The presence of pharmaceutical products in the aquatic environment has been reported in several studies. However, the impact of these drugs on living organisms is still uncharacterized. Here, we investigated the effects of acute exposure to either diazepam or fluoxetine on the stress response in Danio rerio. We showed that diazepam and fluoxetine inhibited the stress axis in zebrafish. Intermediate concentrations of diazepam suppressed the stress response as measured by cortisol levels, whereas fluoxetine inhibited cortisol increase at concentrations similar to those found in the environment. These data suggest that the presence of psychoactive drugs in aquatic ecosystems could cause neuroendocrine dysfunction in fish.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0103232