Randomised double-blind comparison of placebo and active drugs for effects on risks associated with blood pressure variability in the Systolic Hypertension in Europe trial

In the Systolic Hypertension in Europe trial (NCT02088450), we investigated whether systolic blood pressure variability determines prognosis over and beyond level. Using a computerised random function and a double-blind design, we randomly allocated 4695 patients (≥60 years) with isolated systolic h...

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Bibliographic Details
Published in:PloS one 2014-08, Vol.9 (8), p.e103169-e103169
Main Authors: Hara, Azusa, Thijs, Lutgarde, Asayama, Kei, Jacobs, Lotte, Wang, Ji-Guang, Staessen, Jan A
Format: Article
Language:English
Subjects:
Aged
Antihypertensive Agents - pharmacology
Antihypertensive Agents - therapeutic use
Atherosclerosis
Blood
Blood pressure
Blood Pressure - drug effects
Blood pressure measurement
Cardiovascular disease
Cardiovascular diseases
Cerebrovascular system
Clinical trials
Comparative analysis
Complications
Consent
Diabetes
Diuretics
Double-Blind Method
Double-blind studies
Drug Therapy, Combination
Endpoint Determination
Epidemiology
Europe - epidemiology
Female
Follow-Up Studies
Heart
Heart attacks
Heart diseases
Heart failure
Hemodialysis
Humans
Hydrochlorothiazide
Hypertension
Hypertension - drug therapy
Hypertension - mortality
Hypertension - physiopathology
Male
Medicine and Health Sciences
Mercury
Mortality
Multivariate Analysis
Patients
Placebos
Prognosis
Proportional Hazards Models
Randomization
Risk Factors
Sensitivity analysis
Stroke
Studies
Systole - drug effects
Variability
Womens health
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Summary:In the Systolic Hypertension in Europe trial (NCT02088450), we investigated whether systolic blood pressure variability determines prognosis over and beyond level. Using a computerised random function and a double-blind design, we randomly allocated 4695 patients (≥60 years) with isolated systolic hypertension (160-219/
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0103169