Foodborne transmission of bovine spongiform encephalopathy to non-human primates results in preclinical rapid-onset obesity

Obesity has become one of the largest public health challenges worldwide. Recently, certain bacterial and viral pathogens have been implicated in the pathogenesis of obesity. In the present study, we retrospectively analyzed clinical data, plasma samples and post-mortem tissue specimens derived from...

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Bibliographic Details
Published in:PloS one 2014-08, Vol.9 (8), p.e104343
Main Authors: Strom, Alexander, Yutzy, Barbara, Kruip, Carina, Ooms, Mark, Schloot, Nanette C, Roden, Michael, Scott, Fraser W, Loewer, Johannes, Holznagel, Edgar
Format: Article
Language:English
Subjects:
Animals
Autopsy
Biology and life sciences
Body weight
Body weight gain
Bovine spongiform encephalopathy
Brain research
BSE
Cattle
Creutzfeldt-Jakob disease
Data analysis
Data processing
Diabetes
Disease transmission
Dosage
Encephalopathy
Encephalopathy, Bovine Spongiform - complications
Encephalopathy, Bovine Spongiform - metabolism
Encephalopathy, Bovine Spongiform - physiopathology
Encephalopathy, Bovine Spongiform - transmission
Female
Females
Food
Food contamination & poisoning
Foodborne Diseases - physiopathology
Foodborne pathogens
Gastrointestinal system
Gastrointestinal tract
Glucose
Glucose metabolism
Government agencies
Hormones
Humans
Hypoglycemia
Infection
Infections
Macaca fascicularis
Medicine and Health Sciences
Metabolism
Monkeys
Monkeys & apes
Obesity
Obesity - etiology
Obesity - metabolism
Obesity - physiopathology
Pancreas
Pathogenesis
Pathogens
Physiology
Primates
Prions - genetics
Prions - pathogenicity
Proteins
Public health
Risk assessment
Studies
Weight Gain - physiology
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Summary:Obesity has become one of the largest public health challenges worldwide. Recently, certain bacterial and viral pathogens have been implicated in the pathogenesis of obesity. In the present study, we retrospectively analyzed clinical data, plasma samples and post-mortem tissue specimens derived from a risk assessment study in bovine spongiform encephalopathy (BSE)-infected female cynomolgus monkeys (Macaca fascicularis). The original study design aimed to determine minimal infectious doses after oral or intracerebral (i.c.) infection of macaques to assess the risk for humans. High-dose exposures resulted in 100% attack rates and a median incubation time of 4.7 years as described previously. Retrospective analyses of clinical data from high-dosed macaques revealed that foodborne BSE transmission caused rapid weight gain within 1.5 years post infection (β = 0.915; P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0104343