Local and systemic cytokine expression in patients with postherpetic neuralgia

Postherpetic neuralgia (PHN) is the painful complication of a varicella zoster virus reactivation. We investigated the systemic and local gene expression of pro- and anti-inflammatory cytokine expression in patients with PHN. Thirteen patients with PHN at the torso (Th4-S1) were recruited. Skin punc...

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Bibliographic Details
Published in:PloS one 2014-08, Vol.9 (8), p.e105269-e105269
Main Authors: Üçeyler, Nurcan, Valet, Michael, Kafke, Waldemar, Tölle, Thomas R, Sommer, Claudia
Format: Article
Language:English
Subjects:
Activation
Adult
Aged
Aged, 80 and over
Blood
Case-Control Studies
Cytokines
Cytokines - biosynthesis
Cytokines - genetics
Disease control
Female
Gene Expression
Herpes Zoster - blood
Herpes Zoster - immunology
Humans
Inflammation
Interleukin 10
Interleukin 2
Interleukin 6
Interleukin 8
Male
Medicine and Health Sciences
Middle Aged
Neuralgia
Neuralgia, Postherpetic - blood
Neuralgia, Postherpetic - immunology
Neurology
Pain
Pain - blood
Pain - immunology
Patients
Peripheral neuropathy
Rheumatoid arthritis
Skin
Skin - innervation
Skin - metabolism
Torso
Tumor necrosis factor-TNF
Tumor necrosis factor-α
Varicella
Viruses
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Summary:Postherpetic neuralgia (PHN) is the painful complication of a varicella zoster virus reactivation. We investigated the systemic and local gene expression of pro- and anti-inflammatory cytokine expression in patients with PHN. Thirteen patients with PHN at the torso (Th4-S1) were recruited. Skin punch biopsies were obtained from the painful and the contralateral painless body area for intraepidermal nerve fiber density (IENFD) and cytokine profiling. Additionally, blood was withdrawn for systemic cytokine expression and compared to blood values of healthy controls. We analyzed the gene expression of selected pro- and anti-inflammatory cytokines (tumor necrosis factor-alpha [TNF] and interleukins [IL]-1β, IL-2, and IL-8). IENFD was lower in affected skin compared to unaffected skin (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0105269