Diffusion tensor and volumetric magnetic resonance measures as biomarkers of brain damage in a small animal model of HIV

There are currently no widely accepted neuro-HIV small animal models. We wanted to validate the HIV-1 Transgenic rat (Tg) as an appropriate neuro-HIV model and then establish in vivo imaging biomarkers of neuropathology, within this model, using MR structural and diffusion tensor imaging (DTI). Youn...

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Bibliographic Details
Published in:PloS one 2014-08, Vol.9 (8), p.e105752-e105752
Main Authors: Lentz, Margaret R, Peterson, Kristin L, Ibrahim, Wael G, Lee, Dianne E, Sarlls, Joelle, Lizak, Martin J, Maric, Dragan, Reid, William C, Hammoud, Dima A
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
Aging
AIDS
Animal models
Animals
Anisotropy
Biological markers
Biology and Life Sciences
Biomarkers
Biomarkers - metabolism
Brain
Brain damage
Brain Injuries - metabolism
Brain Injuries - pathology
Brain injury
Brain research
Cognitive ability
Corpus callosum
Corpus Callosum - metabolism
Corpus Callosum - pathology
Degeneration
Dementia
Demyelination
Dietary fiber
Diffusion
Disease Models, Animal
Eigen values
Eigenvalues
Gene expression
Genetic engineering
HIV
HIV Infections - metabolism
HIV Infections - pathology
HIV-1
Human immunodeficiency virus
Humans
Immunofluorescence
Infections
Infectious diseases
Magnetic resonance
Magnetic resonance imaging
Medicine and Health Sciences
Neostriatum
Neurodegeneration
Neuroimaging
Neurological disorders
NMR
Nuclear magnetic resonance
Physical Sciences
Rats
Rats, Inbred F344
Rats, Transgenic
Research and Analysis Methods
Substantia alba
Transgenic
Ventricle
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Summary:There are currently no widely accepted neuro-HIV small animal models. We wanted to validate the HIV-1 Transgenic rat (Tg) as an appropriate neuro-HIV model and then establish in vivo imaging biomarkers of neuropathology, within this model, using MR structural and diffusion tensor imaging (DTI). Young and middle-aged Tg and control rats were imaged using MRI. A subset of middle-aged animals underwent longitudinal repeat imaging six months later. Total brain volume (TBV), ventricular volume (VV) and parenchymal volume (PV = TBV-VV) were measured. Fractional anisotropy (FA) and mean diffusivity (MD) values of the corpus callosum (CC) were calculated from DTI data. TBV and PV were smaller in Tg compared to control rats in young and middle-aged cohorts (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0105752