Portable optical epidural needle-a CMOS-based system solution and its circuit design

Epidural anesthesia is a common anesthesia method yet up to 10% of procedures fail to provide adequate analgesia. This is usually due to misinterpreting the tactile information derived from the advancing needle through the complex tissue planes. Incorrect placement also can cause dural puncture and...

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Bibliographic Details
Published in:PloS one 2014-08, Vol.9 (8), p.e106055-e106055
Main Authors: Gong, Cihun-Siyong Alex, Lin, Shih-Pin, Mandell, M Susan, Tsou, Mei-Yung, Chang, Yin, Ting, Chien-Kun
Format: Article
Language:English
Subjects:
Analgesia
Anesthesia
Anesthesia, Epidural - instrumentation
Anesthesiology
Animals
Circuit design
CMOS
Complementary metal oxide semiconductors
Computer engineering
Discriminant analysis
Engineering and Technology
Engineering schools
Epidural Space - anatomy & histology
Evaluation
Feasibility studies
Fiber Optic Technology - instrumentation
Hogs
Innovations
Integrated circuits
Lab-On-A-Chip Devices
Laboratories
Medicine and Health Sciences
Needles
New technology
Optics
Pain perception
Planes
ROC Curve
Semiconductors
Spine
Spine (lumbar)
Swine
Technology
Thoracic Vertebrae - anatomy & histology
Ultrasonic imaging
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Summary:Epidural anesthesia is a common anesthesia method yet up to 10% of procedures fail to provide adequate analgesia. This is usually due to misinterpreting the tactile information derived from the advancing needle through the complex tissue planes. Incorrect placement also can cause dural puncture and neural injury. We developed an optic system capable of reliably identifying tissue planes surrounding the epidural space. However the new technology was too large and cumbersome for practical clinical use. We present a miniaturized version of our optic system using chip technology (first generation CMOS-based system) for logic functions. The new system was connected to an alarm that was triggered once the optic properties of the epidural were identified. The aims of this study were to test our miniaturized system in a porcine model and describe the technology to build this new clinical tool. Our system was tested in a porcine model and identified the epidural space in the lumbar, low and high thoracic regions of the spine. The new technology identified the epidural space in all but 1 of 46 attempts. Experimental results from our fabricated integrated circuit and animal study show the new tool has future clinical potential.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0106055