Urinary nerve growth factor could be a biomarker for interstitial cystitis/painful bladder syndrome: a meta-analysis

To examine whether urinary nerve growth factor (NGF) could serve as a biomarker for interstitial cystitis/painful bladder syndrome (IC/PBS), we conducted a comprehensive meta-analysis of 9 studies. Among the studies considered, patients with IC/PBS had higher urinary NGF and NGF/Cr levels compared t...

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Bibliographic Details
Published in:PloS one 2014-09, Vol.9 (9), p.e106321-e106321
Main Authors: Qu, Hong-Chen, Zhang, Wei, Yan, Shi, Liu, Yi-Li, Wang, Ping
Format: Article
Language:English
Subjects:
Biology and Life Sciences
Biomarkers
Biomarkers - urine
Bladder
Case-Control Studies
Comparative analysis
Creatinine - urine
Cystitis
Cystitis, Interstitial - therapy
Cystitis, Interstitial - urine
Diagnosis
Differential diagnosis
Growth factors
Humans
Inflammation
Medical ethics
Medicine and Health Sciences
Meta-analysis
Nerve growth factor
Nerve Growth Factor - urine
Pain
Patients
Proteins
Publication Bias
Rodents
Sensitivity and Specificity
Studies
Surgery
Systematic review
Treatment Outcome
Urinary bladder
Urinary Bladder, Overactive - urine
Urinary incontinence
Urine
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Summary:To examine whether urinary nerve growth factor (NGF) could serve as a biomarker for interstitial cystitis/painful bladder syndrome (IC/PBS), we conducted a comprehensive meta-analysis of 9 studies. Among the studies considered, patients with IC/PBS had higher urinary NGF and NGF/Cr levels compared to those of healthy people (SMD = 1.94, 95%CI = 0.79-3.08, P = 0.0009 and SMD = 1.79, 95%CI = 0.65-2.93, P = 0.002, respectively). In addition, there was a significant difference between patients with IC/PBS and patients with overactive bladder (OAB) symptoms with respect to the urinary NGF and NGF/Cr levels (SMD = -0.62, 95%CI = -1.00--0.24, P = 0.001 and SMD = -0.70, 95%CI = -1.01--0.39, P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0106321