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Exercise-induced norepinephrine decreases circulating hematopoietic stem and progenitor cell colony-forming capacity

A recent study showed that ergometry increased circulating hematopoietic stem and progenitor cell (CPC) numbers, but reduced hematopoietic colony forming capacity/functionality under normoxia and normobaric hypoxia. Herein we investigated whether an exercise-induced elevated plasma free/bound norepi...

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Published in:PloS one 2014-09, Vol.9 (9), p.e106120
Main Authors: Kröpfl, Julia M, Stelzer, Ingeborg, Mangge, Harald, Pekovits, Karin, Fuchs, Robert, Allard, Nathalie, Schinagl, Lukas, Hofmann, Peter, Dohr, Gottfried, Wallner-Liebmann, Sandra, Domej, Wolfgang, Müller, Wolfram
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Language:English
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Summary:A recent study showed that ergometry increased circulating hematopoietic stem and progenitor cell (CPC) numbers, but reduced hematopoietic colony forming capacity/functionality under normoxia and normobaric hypoxia. Herein we investigated whether an exercise-induced elevated plasma free/bound norepinephrine (NE) concentration could be responsible for directly influencing CPC functionality. Venous blood was taken from ten healthy male subjects (25.3+/-4.4 yrs) before and 4 times after ergometry under normoxia and normobaric hypoxia (FiO2
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0106120