Dual-phase cardiac diffusion tensor imaging with strain correction

In this work we present a dual-phase diffusion tensor imaging (DTI) technique that incorporates a correction scheme for the cardiac material strain, based on 3D myocardial tagging. In vivo dual-phase cardiac DTI with a stimulated echo approach and 3D tagging was performed in 10 healthy volunteers. T...

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Bibliographic Details
Published in:PloS one 2014-09, Vol.9 (9), p.e107159-e107159
Main Authors: Stoeck, Christian T, Kalinowska, Aleksandra, von Deuster, Constantin, Harmer, Jack, Chan, Rachel W, Niemann, Markus, Manka, Robert, Atkinson, David, Sosnovik, David E, Mekkaoui, Choukri, Kozerke, Sebastian
Format: Article
Language:English
Subjects:
Adult
Angle of reflection
Anisotropy
Architecture
Biology and Life Sciences
Biomedical engineering
Breath Holding
Cardiology
Comparative analysis
Contraction
Data acquisition
Diastole
Diastole - physiology
Diffusion
Diffusion effects
Diffusion Tensor Imaging - methods
Engineering
Engineering and Technology
Female
Heart
Heart - physiology
Heart diseases
Heart Rate
Histograms
Hospitals
Humans
Image Processing, Computer-Assisted - methods
Imaging, Three-Dimensional - methods
In vivo methods and tests
Magnetic resonance imaging
Male
Marking
Medical imaging
Medicine and Health Sciences
Microscopy
Movement - physiology
Myocardium - pathology
NMR
Nuclear magnetic resonance
Systole
Systole - physiology
Tagging
Young Adult
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Summary:In this work we present a dual-phase diffusion tensor imaging (DTI) technique that incorporates a correction scheme for the cardiac material strain, based on 3D myocardial tagging. In vivo dual-phase cardiac DTI with a stimulated echo approach and 3D tagging was performed in 10 healthy volunteers. The time course of material strain was estimated from the tagging data and used to correct for strain effects in the diffusion weighted acquisition. Mean diffusivity, fractional anisotropy, helix, transverse and sheet angles were calculated and compared between systole and diastole, with and without strain correction. Data acquired at the systolic sweet spot, where the effects of strain are eliminated, served as a reference. The impact of strain correction on helix angle was small. However, large differences were observed in the transverse and sheet angle values, with and without strain correction. The standard deviation of systolic transverse angles was significantly reduced from 35.9±3.9° to 27.8°±3.5° (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0107159