Subfoveal choroidal thickness and glaucoma. The Beijing Eye Study 2011

• Published in: PloS one 2014-09, Vol.9 (9), p.e107321
• Main Authors: Wang, Ya Xing, Xu, Liang, Shao, Lei, Zhang, Ya Qin, Yang, Hua, Da Wang, Jin, Jonas, Jost B, Wei, Wen Bin
• Format: Article
• Language: English
• Subjects: Age; Aged; Aged, 80 and over; Anterior chamber; Authorship; Biology and Life Sciences; Choroid - pathology; Cross-Sectional Studies; Diabetes; Diabetic retinopathy; Eye; Eye lens; Female; Fovea Centralis - pathology; Glaucoma; Glaucoma, Angle-Closure - pathology; Glaucoma, Open-Angle - pathology; Humans; Intraocular pressure; Male; Medical imaging; Medicine and Health Sciences; Middle Aged; Multivariate analysis; Optic nerve; Optical Coherence Tomography; Optics; Patients; Population studies; Regression analysis; Regression coefficients; Research and Analysis Methods; Studies; Tomography; Tomography, Optical Coherence
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0107321

To examine subfoveal choroidal thickness (SFCT) in eyes with glaucoma, using enhanced depth imaging spectral domain optical coherence tomography. The population-based Beijing Eye Study 2011 included 3468 individuals with a mean age of 64.6 ± 9.8 years (range: 50-93 years). A detailed ophthalmic examination was performed including spectral-domain optical coherence tomography (SD-OCT) with enhanced depth imaging for measurement of SFCT, and assessment of fundus photographs for presence of glaucoma. In addition, the group of patients with chronic angle-closure glaucoma (ACG) from the Beijing Eye Study (n = 37) was merged with a group of patients with chronic ACG from the Tongren hospital (n = 52). Assessments of SFCT and glaucoma were available for 3232 (93.2%) subjects. After adjusting for age, axial length, gender, anterior chamber and lens thickness, SFCT was not significantly associated with presence of glaucoma (P = 0.08; regression coefficient B:-15.7). As a corollary, in logistic regression analysis with adjustment for age, axial length and intraocular pressure, presence of glaucoma was not significantly associated with SFCT (P = 0.20). If only open-angle glaucoma was considered, multivariate analysis revealed no significant association between SFCT and presence of open-angle glaucoma (P = 0.44). As a corollary, in logistic regression analysis, open-angle glaucoma was not significantly associated with SFCT (P = 0.91). In a similar manner if only ACG was taken into account, SFCT was not significantly associated with the presence of ACG (P = 0.27) in multivariate analysis. As a corollary in binary regression analysis, presence of ACG was not significantly associated with SFCT (P = 0.27). In multivariate analysis with adjustment for age, axial length, gender, anterior chamber and lens thickness, neither OAG nor ACG was associated with an abnormal SFCT.