Dynamics of cell shape inheritance in fission yeast

Every cell has a characteristic shape key to its fate and function. That shape is not only the product of genetic design and of the physical and biochemical environment, but it is also subject to inheritance. However, the nature and contribution of cell shape inheritance to morphogenetic control is...

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Bibliographic Details
Published in:PloS one 2014-09, Vol.9 (9), p.e106959-e106959
Main Authors: Abenza, Juan F, Chessel, Anatole, Raynaud, William G, Carazo-Salas, Rafael E
Format: Article
Language:English
Subjects:
Biology and Life Sciences
Cell division
Cell Polarity - genetics
Cell Polarity - physiology
Cell Shape - genetics
Cell Shape - physiology
Cell size
Chromatin Assembly and Disassembly - genetics
Chromatin remodeling
Daughters
Fission
Genes
Genomics
Heredity
Kinases
Metabolic Networks and Pathways - genetics
Microtubules - genetics
Molecular chains
Morphology
Mutants
Mutation
Polarity
Protein Transport - physiology
Proteins
Research and Analysis Methods
Schizosaccharomyces - genetics
Schizosaccharomyces - growth & development
Schizosaccharomyces pombe
Yeast
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Summary:Every cell has a characteristic shape key to its fate and function. That shape is not only the product of genetic design and of the physical and biochemical environment, but it is also subject to inheritance. However, the nature and contribution of cell shape inheritance to morphogenetic control is mostly ignored. Here, we investigate morphogenetic inheritance in the cylindrically-shaped fission yeast Schizosaccharomyces pombe. Focusing on sixteen different 'curved' mutants--a class of mutants which often fail to grow axially straight--we quantitatively characterize their dynamics of cell shape inheritance throughout generations. We show that mutants of similar machineries display similar dynamics of cell shape inheritance, and exploit this feature to show that persistent axial cell growth in S. pombe is secured by multiple, separable molecular pathways. Finally, we find that one of those pathways corresponds to the swc2-swr1-vps71 SWR1/SRCAP chromatin remodelling complex, which acts additively to the known mal3-tip1-mto1-mto2 microtubule and tea1-tea2-tea4-pom1 polarity machineries.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0106959