The role of catechol-O-methyl transferase Val(108/158)Met polymorphism (rs4680) in the effect of green tea on resting energy expenditure and fat oxidation: a pilot study

Green tea(GT) is able to increase energy expenditure(EE) and fat oxidation(FATox) via inhibition of catechol-O-methyl transferase(COMT) by catechins. However, this does not always appear unanimously because of large inter-individual variability. This may be explained by different alleles of the func...

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Bibliographic Details
Published in:PloS one 2014-09, Vol.9 (9), p.e106220
Main Authors: Hursel, Rick, Janssens, Pilou L H R, Bouwman, Freek G, Mariman, Edwin C, Westerterp-Plantenga, Margriet S
Format: Article
Language:English
Subjects:
Adult
Alcohol
Alleles
Biology
Biology and Life Sciences
Body mass
Caffeine
Camellia sinensis - chemistry
Carbohydrates
Catechin
Catechin - pharmacology
Catechol
Catechol O-Methyltransferase - chemistry
Catechol O-Methyltransferase - genetics
Clean energy
Cross-Over Studies
Energy
Energy expenditure
Energy Metabolism - genetics
Enzymatic activity
Enzyme activity
Enzymes
European Continental Ancestry Group - genetics
Female
Flavonoids
Gene polymorphism
Genotype
Genotype & phenotype
Genotypes
Green tea
Humans
Ingestion
Lipid Metabolism - genetics
Male
Medicine and Health Sciences
Metabolism
Metabolites
Nutrition
Oxidation
Oxidation-Reduction
Pilot Projects
Polymorphism
Polymorphism, Genetic
Polyphenols
Questionnaires
Research and Analysis Methods
Substrates
Tea
Thermogenesis
Toxicology
Variability
Ventilation
White people
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Summary:Green tea(GT) is able to increase energy expenditure(EE) and fat oxidation(FATox) via inhibition of catechol-O-methyl transferase(COMT) by catechins. However, this does not always appear unanimously because of large inter-individual variability. This may be explained by different alleles of the functional COMT Val108/158Met polymorphism that are associated with COMT enzyme activity; high-activity enzyme, COMT(H)(Val/Val genotype), and low-activity COMT(L)(Met/Met genotype). Fourteen Caucasian subjects (BMI: 22.2±2.3 kg/m2, age: 21.4±2.2 years) of whom 7 with the COMT(H)-genotype and 7 with the COMT(L)-genotype were included in a randomized, cross-over study in which EE and substrate oxidation were measured with a ventilated-hood system after decaffeinated GT and placebo(PL) consumption. At baseline, EE, RQ, FATox and carbohydrate oxidation(CHOox) did not differ between groups. Significant interactions were observed between COMT genotypes and treatment for RQ, FATox and CHOox (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0106220