The correlation between lung sound distribution and pulmonary function in COPD patients

• Published in: PloS one 2014-09, Vol.9 (9), p.e107506-e107506
• Main Authors: Mineshita, Masamichi, Kida, Hirotaka, Handa, Hiroshi, Nishine, Hiroki, Furuya, Naoki, Nobuyama, Seiichi, Inoue, Takeo, Matsuoka, Shin, Miyazawa, Teruomi
• Format: Article
• Language: English
• Subjects: Acoustic properties; Aged; Aged, 80 and over; Airway management; Analysis; Asthma; Bronchodilators; Chronic obstructive lung disease; Chronic obstructive pulmonary disease; Computed tomography; Correlation; Data processing; Diaphragm; Diaphragm (anatomy); Emphysema; Female; Hospitals; Humans; Infectious diseases; Inhalation; Internal medicine; Lesions; Lung - diagnostic imaging; Lung - physiopathology; Lung diseases; Male; Medical imaging; Medicine; Medicine and Health Sciences; Middle Aged; Obstructive lung disease; Patients; Physiology; Pulmonary Disease, Chronic Obstructive - diagnostic imaging; Pulmonary Disease, Chronic Obstructive - physiopathology; Pulmonary Emphysema - diagnostic imaging; Pulmonary Emphysema - physiopathology; Pulmonary functions; Radiography; Research and Analysis Methods; Respiration; Respiratory function; Respiratory Function Tests; Respiratory Sounds - physiopathology; Severity of Illness Index; Sound; Sound intensity; Test procedures; X rays
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0107506

Regional lung sound intensity in chronic obstructive pulmonary disease (COPD) patients is influenced by the severity and distribution of emphysema, obstructed peripheral airways, and altered ribcage and diaphragm configurations and movements due to hyperinflation. Changes in the lung sound distribution accompanied by pulmonary function improvements in COPD patients were observed after bronchodilator inhalation. We investigated the association of lung sound distribution with pulmonary functions, and the effects of emphysematous lesions on this association. These studies were designed to acquire the basic knowledge necessary for the application of lung sound analysis in the physiological evaluation of COPD patients. Pulmonary function tests and the percentage of upper- and lower-lung sound intensity (quantitative lung data [QLD]) were evaluated in 47 stable male COPD patients (54 - 82 years of age). In 39 patients, computed tomography taken within 6 months of the study was available and analyzed. The ratio of lower QLD to upper QLD showed significant positive correlations with FEV1 %predicted (%FEV1; ρ=0.45, p