Genetic diversity and levels of expression of factor H binding protein among carriage isolates of Neisseria meningitidis

The prevention of meningococcal disease may be improved by recombinant vaccines such as 4CMenB and rLP2086 that target the factor H binding protein (fHbp), an immunogenic surface component of Neisseria meningitidis present as one of three variants. Whether such vaccines decrease carriage of invasive...

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Bibliographic Details
Published in:PloS one 2014-09, Vol.9 (9), p.e107240-e107240
Main Authors: Lemée, Ludovic, Hong, Eva, Etienne, Manuel, Deghmane, Ala-Eddine, Delbos, Valérie, Terrade, Aude, Berthelot, Gilles, Caron, Francois, Taha, Muhamed-Kheir
Format: Article
Language:English
Subjects:
Adolescent
Adult
Analysis
Antibodies
Antigens, Bacterial
Antigens, Bacterial - genetics
Antigens, Bacterial - immunology
Bacterial infections
Bacterial Proteins
Bacterial Proteins - genetics
Bacterial Proteins - immunology
Bacterial Typing Techniques
Bacteriology
Binding
Biodiversity
Biology and Life Sciences
Carrier State
Carrier State - microbiology
Child
Child, Preschool
Disease
Epidemics
Gene Expression Regulation, Bacterial
Gene sequencing
Genetic diversity
Genetic Variation
Genetics
Herd immunity
Human health and pathology
Humans
Immunity
Immunogenicity
Infant
Infections
Infectious diseases
Life Sciences
Medicine and Health Sciences
Meningitis
Meningococcal disease
Meningococcal Infections
Meningococcal Infections - microbiology
Microbiology and Parasitology
Neisseria meningitidis
Neisseria meningitidis - classification
Neisseria meningitidis - genetics
Neisseria meningitidis - isolation & purification
Phylogeny
Protein binding
Proteins
Sequence Analysis, DNA
Vaccines
Young Adult
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Summary:The prevention of meningococcal disease may be improved by recombinant vaccines such as 4CMenB and rLP2086 that target the factor H binding protein (fHbp), an immunogenic surface component of Neisseria meningitidis present as one of three variants. Whether such vaccines decrease carriage of invasive isolates and thus induce herd immunity is unknown. We analyzed the genetic diversity and levels of expression of fHbp among 268 carriage strains and compare them to those of 467 invasive strains. fhbp gene sequencing showed higher proportions of variants 2 and 3 among carriage isolates (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0107240