Cardiovascular magnetic resonance imaging of scar development following pulmonary vein isolation: a prospective study

Cardiovascular magnetic resonance (MR) provides non-invasive assessment of early (24-hour) edema and injury following pulmonary vein isolation (by ablation) and subsequent scar formation. We hypothesize that 24-hours after ablation, cardiovascular MR would demonstrate a pattern of edema and injury d...

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Bibliographic Details
Published in:PloS one 2014-09, Vol.9 (9), p.e104844-e104844
Main Authors: Hsing, Jeff, Peters, Dana C, Knowles, Benjamin R, Manning, Warren J, Josephson, Mark E
Format: Article
Language:English
Subjects:
Ablation
Adult
Atrial Fibrillation - therapy
Cardiac arrhythmia
Cardiovascular System - diagnostic imaging
Cardiovascular System - pathology
Catheter Ablation - adverse effects
Catheter Ablation - methods
Catheters
Cicatrix - diagnosis
Cicatrix - diagnostic imaging
Cicatrix - etiology
Contrast Media
Correlation
Edema
Edema - diagnosis
Edema - diagnostic imaging
Edema - etiology
Female
Fibrillation
Gadolinium
Gadolinium DTPA
Gangrene
Humans
Image Enhancement - methods
Injuries
Linear Models
Magnetic resonance
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Male
Medical imaging
Medical schools
Medicine
Medicine and Health Sciences
Middle Aged
Neural networks
NMR
Nuclear magnetic resonance
Prospective Studies
Pulmonary Veins - diagnostic imaging
Pulmonary Veins - pathology
Radiography
Reproducibility of Results
Resonance
Scars
Sensitivity
Sensitivity analysis
Sensitivity and Specificity
Studies
Thickening
Time Factors
Veins & arteries
Wall thickness
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Summary:Cardiovascular magnetic resonance (MR) provides non-invasive assessment of early (24-hour) edema and injury following pulmonary vein isolation (by ablation) and subsequent scar formation. We hypothesize that 24-hours after ablation, cardiovascular MR would demonstrate a pattern of edema and injury due to ablation and the severity would correlate with subsequent scar. Fifteen atrial fibrillation patients underwent cardiovascular MR prior to pulmonary vein isolation, 24-hours post (N = 11) and 30-days post (N = 7) ablation, with T2-weighted (T2W) and late gadolinium enhancement (LGE) imaging. Left atrial wall thickness, edema enhancement ratio and LGE enhancement were assessed at each time point. Volumes of LGE and edema enhancement were measured, and the circumferential presence of injury was assessed at 24-hours, including comparison with LGE enhancement at 30 days. Left atrial wall thickness was increased 24-hours post-ablation (10.7 ± 4.1 mm vs. 7.0 ± 1.8 mm pre-PVI, p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0104844