Defining the role of medication adherence in poor glycemic control among a general adult population with diabetes

This study assesses the attributable impact of adherence to oral glucose medications as a risk factor for poor glycemic control in population subgroups of a large general population, using an objective medication adherence measure. Using electronic health records data, adherence to diabetes medicati...

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Bibliographic Details
Published in:PloS one 2014-09, Vol.9 (9), p.e108145-e108145
Main Authors: Feldman, Becca S, Cohen-Stavi, Chandra J, Leibowitz, Morton, Hoshen, Moshe B, Singer, Shepherd R, Bitterman, Haim, Lieberman, Nicky, Balicer, Ran D
Format: Article
Language:English
Subjects:
Adhesion
Adult
Adults
Age
Aged
Aged, 80 and over
Blood Glucose
Diabetes
Diabetes mellitus
Diabetes Mellitus - blood
Diabetes Mellitus - drug therapy
Diabetes Mellitus - epidemiology
Disease control
Drugs
Electronic health records
Electronic medical records
Female
Glucose
Glycated Hemoglobin A
Health services
Hemoglobin
Humans
Hypoglycemic Agents - therapeutic use
Laboratories
Male
Measurement methods
Medication Adherence
Medicine
Medicine and Health Sciences
Metabolism
Middle Aged
Mortality
Patient compliance
Patients
Physicians
Population
Primary care
Public Health Surveillance
Regression analysis
Regression models
Risk Factors
Studies
Subgroups
Treatment Outcome
Young Adult
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Summary:This study assesses the attributable impact of adherence to oral glucose medications as a risk factor for poor glycemic control in population subgroups of a large general population, using an objective medication adherence measure. Using electronic health records data, adherence to diabetes medications over a two-year period was calculated by prescription-based Medication Possession Ratios for adults with diabetes diagnosed before January 1, 2010. Glycemic control was determined by the HbA1c test closest to the last drug prescription during 2010-2012. Poor control was defined as HbA1c>75 mmol/mol (9.0%). Medication adherence was categorized as "good" (>80%), "moderate" (50-80%), or "poor" (
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0108145