Diagnostic efficacy of cell block immunohistochemistry, smear cytology, and liquid-based cytology in endoscopic ultrasound-guided fine-needle aspiration of pancreatic lesions: a single-institution experience

The diagnostic efficiency of endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) cytology varies widely depending on the treatment method of the specimens. The present study aimed to evaluate the diagnostic efficacy of cell block (CB) immunohistochemistry, smear cytology (SC), and liquid-b...

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Bibliographic Details
Published in:PloS one 2014-09, Vol.9 (9), p.e108762-e108762
Main Authors: Qin, Shan-Yu, Zhou, You, Li, Ping, Jiang, Hai-Xing
Format: Article
Language:English
Subjects:
Accuracy
Adult
Aged
Catheters
Cellular biology
Comparative analysis
Cytodiagnosis - methods
Cytology
Diagnostic systems
Effectiveness
Endoscopes
Endoscopic ultrasonography
Endoscopic Ultrasound-Guided Fine Needle Aspiration - methods
Endoscopy
Family medical history
Female
Gastroenterology
Humans
Immunohistochemistry
Immunohistochemistry - methods
Laboratories
Lesions
Male
Medical diagnosis
Medicine and Health Sciences
Methods
Middle Aged
Pancreas
Pancreas - pathology
Pancreatic Neoplasms - diagnosis
Pancreatic Neoplasms - metabolism
Pancreatic Neoplasms - pathology
Patients
Predictive Value of Tests
Sensitivity and Specificity
Smear
Studies
Surgery
Tumors
Ultrasonic imaging
Ultrasound
Young Adult
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Summary:The diagnostic efficiency of endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) cytology varies widely depending on the treatment method of the specimens. The present study aimed to evaluate the diagnostic efficacy of cell block (CB) immunohistochemistry, smear cytology (SC), and liquid-based cytology (LBC) in patients with pancreatic lesions without consulting an on-site cytopathologist. This study prospectively enrolled 72 patients with pancreatic lesions. The EUS-FNA specimens were examined by SC, LBC, and CB immunohistochemistry. The diagnostic efficacy of the 3 methods was then compared. Patients' final diagnosis was confirmed by surgical resection specimens, diagnostic imaging, and clinical follow-up. Our results included 60 malignant and 12 benign pancreatic lesions. The diagnostic sensitivity (90%), negative predictive value (66.7%), and accuracy (91.7%) of CB immunohistochemistry were significantly higher than those of SC (70.0%, 30.0%, and 75.0%, respectively) and LBC (73.3%, 31.6%, and 77.8%, respectively) (all P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0108762