Lactobacillus rossiae, a vitamin B12 producer, represents a metabolically versatile species within the Genus Lactobacillus

Lactobacillus rossiae is an obligately hetero-fermentative lactic acid bacterium, which can be isolated from a broad range of environments including sourdoughs, vegetables, fermented meat and flour, as well as the gastrointestinal tract of both humans and animals. In order to unravel distinctive gen...

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Bibliographic Details
Published in:PloS one 2014-09, Vol.9 (9), p.e107232-e107232
Main Authors: De Angelis, Maria, Bottacini, Francesca, Fosso, Bruno, Kelleher, Philip, Calasso, Maria, Di Cagno, Raffaella, Ventura, Marco, Picardi, Ernesto, van Sinderen, Douwe, Gobbetti, Marco
Format: Article
Language:English
Subjects:
Bacteria
Bioinformatics
Biology and Life Sciences
Biotechnology
Carbon sources
Chromosomes
Cyanocobalamin
Fermentation
Fermented food
Folic acid
Food
Gastrointestinal tract
Genes
Genes, Bacterial
Genomes
Lactic acid
Lactobacillus
Lactobacillus - classification
Lactobacillus - genetics
Lactobacillus - metabolism
Lactobacillus casei
Lactobacillus johnsonii
Lactobacillus plantarum
Meat
Metabolism
Microbiota
Niches
Phylogeny
Probiotics
Proteins
Riboflavin
Triticum
Vegetables
Vitamin B 12 - biosynthesis
Vitamin B12
Vitamins
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Description
Summary:Lactobacillus rossiae is an obligately hetero-fermentative lactic acid bacterium, which can be isolated from a broad range of environments including sourdoughs, vegetables, fermented meat and flour, as well as the gastrointestinal tract of both humans and animals. In order to unravel distinctive genomic features of this particular species and investigate the phylogenetic positioning within the genus Lactobacillus, comparative genomics and phylogenomic approaches, followed by functional analyses were performed on L. rossiae DSM 15814T, showing how this type strain not only occupies an independent phylogenetic branch, but also possesses genomic features underscoring its biotechnological potential. This strain in fact represents one of a small number of bacteria known to encode a complete de novo biosynthetic pathway of vitamin B12 (in addition to other B vitamins such as folate and riboflavin). In addition, it possesses the capacity to utilize an extensive set of carbon sources, a characteristic that may contribute to environmental adaptation, perhaps enabling the strain's ability to populate different niches.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0107232