Low-level carotid baroreceptor stimulation suppresses ventricular arrhythmias during acute ischemia

• Published in: PloS one 2014-10, Vol.9 (10), p.e109313-e109313
• Main Authors: Liao, Kai, Yu, Lilei, Yang, Kang, Saren, Gaowa, Wang, Songyun, Huang, Bing, Jiang, Hong
• Format: Article
• Language: English
• Subjects: Action potential; Action Potentials; Acute Disease; Animals; Arrhythmia; Arrhythmias, Cardiac - complications; Autonomic nervous system; Blood; Blood pressure; Cardiac arrhythmia; Cardiology; Carotid arteries; Carotid Arteries - metabolism; Coronary Occlusion - complications; Dogs; Electric Stimulation; Electrodes; Event-related potentials; Evoked Potentials; Fibrillation; Heart attacks; Heart failure; Heart rate; Heart Ventricles - physiopathology; Hemodynamics; High frequencies; Hospitals; Hypertension; Ischemia; Laboratory animals; Level (quantity); Levels; Male; Medicine and Health Sciences; Myocardial Ischemia - complications; Myocardial Ischemia - metabolism; Myocardial Ischemia - physiopathology; Myocardial Ischemia - therapy; Nervous system; Occlusion; Pressoreceptors - metabolism; Rodents; Stellate ganglion; Stellate Ganglion - physiopathology; Stimulation; Variability; Veins & arteries; Ventricle; Ventricular fibrillation
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0109313

The autonomic imbalance during acute ischemia is involved in the occurrence of life-threatening arrhythmias. To investigate the effect of autonomic nervous system (ANS) modulation by low-level carotid baroreceptor stimulation (LL-CBS) on ventricular ischemia arrhythmias. Anesthetized dogs were received either sham treatment (SHAM group, n = 10) or LL-CBS treatment (LL-CBS group, n = 10). The voltage lowering the blood pressure was used as the threshold for setting LL-CBS at 80% below the threshold. Treatment started 1 hour before left anterior descending coronary (LAD) occlusion, and continued until the end of experience. Ventricular effective refractory periods (ERP), monophasic action potential duration at 90% (APD90), ventricular arrhythmias, indices of heart rate variability, left stellate ganglion nerve activity (LSGNA) and infarct sizes were measured and analyzed. Ventricular ischemia resulted in an acute reduction of blood pressure, which was not significantly affected by LL-CBS. After 1 hour of LL-CBS, there was a progressive and significant increase in ERP, increase in APD90, and decrease in LSGNA vs the SHAM group (all P