External validation of the A2DS2 score to predict stroke-associated pneumonia in a Chinese population: a prospective cohort study

The A2DS2 score was recently developed from the Berlin Stroke Registry for predicting in-hospital pneumonia after acute ischemic stroke and performed well in an external validation in the North-west Germany Stroke Registry. It could be a useful tool for risk stratification in clinical practice or st...

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Bibliographic Details
Published in:PloS one 2014, Vol.9 (10), p.e109665-e109665
Main Authors: Li, Yapeng, Song, Bo, Fang, Hui, Gao, Yuan, Zhao, Lu, Xu, Yuming
Format: Article
Language:English
Subjects:
Age
Aged
Aged, 80 and over
Alcohol
Brain Ischemia - complications
Brain Ischemia - diagnosis
Brain Ischemia - pathology
Calibration
Cardiovascular disease
China
Clinical medicine
Clinical trials
Cohort analysis
Confidence intervals
Consciousness
Demographics
Diabetes
Disease control
Dysphagia
Female
Goodness of fit
Health risk assessment
Humans
Hypertension
Ischemia
Male
Mathematical models
Medicine and Health Sciences
Middle Aged
Mortality
Neurology
Nosocomial infections
Patients
Pneumonia
Pneumonia - diagnosis
Pneumonia - etiology
Pneumonia - pathology
Population
Population studies
Prognosis
Prospective Studies
Risk Assessment
Risk Factors
Risk groups
ROC Curve
Severity of Illness Index
Statistical analysis
Statistical tests
Stroke
Stroke - complications
Stroke - diagnosis
Stroke - pathology
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Summary:The A2DS2 score was recently developed from the Berlin Stroke Registry for predicting in-hospital pneumonia after acute ischemic stroke and performed well in an external validation in the North-west Germany Stroke Registry. It could be a useful tool for risk stratification in clinical practice or stroke trials. We aimed to prospectively validate the predictive value of A2DS2 score in a Chinese stroke population. The prognostic model was used to predict stroke-associated pneumonia (SAP) from Henan Province Stroke Registry (HNSR) in which data were prospectively collected. The receiver-operating characteristic curves were plotted, and the C statistics were calculated to assess the discrimination ability. The Hosmer-Lemeshow goodness-of-fit test and the plot of observed versus predicted SAP risk were used to assess model calibration. Among 1142 eligible patients, the overall in-hospital SAP was 18.8%, which ranged from 9.0% in patients with lower A2DS2 scores (0-4) to 65.0% in those with higher scores of 5 to 10 (P for trend
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0109665