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Nonmotor symptoms in LRRK2 G2019S associated Parkinson's disease
Idiopathic Parkinson's disease (IPD) and LRRK2-associated PD (LRRK2-PD) might be expected to differ clinically since the neuropathological substrate of LRRK2-PD is heterogeneous. The range and severity of extra-nigral nonmotor features associated with LRRK2 mutations is also not well-defined. T...
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| Published in: | PloS one 2014-10, Vol.9 (10), p.e108982-e108982 |
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| container_end_page | e108982 |
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| creator | Gaig, Carles Vilas, Dolores Infante, Jon Sierra, María García-Gorostiaga, Inés Buongiorno, Mariateresa Ezquerra, Mario Martí, Maria José Valldeoriola, Francesc Aguilar, Miquel Calopa, Matilde Hernandez-Vara, Jorge Tolosa, Eduardo |
| description | Idiopathic Parkinson's disease (IPD) and LRRK2-associated PD (LRRK2-PD) might be expected to differ clinically since the neuropathological substrate of LRRK2-PD is heterogeneous. The range and severity of extra-nigral nonmotor features associated with LRRK2 mutations is also not well-defined.
To evaluate the prevalence and time of onset of nonmotor symptoms (NMS) in LRRK2-PD patients.
The presence of hyposmia and of neuropsychiatric, dysautonomic and sleep disturbances was assessed in 33 LRRK2-G2019S-PD patients by standardized questionnaires and validated scales. Thirty-three IPD patients, matched for age, gender, duration of parkinsonism and disease severity and 33 healthy subjects were also evaluated.
University of Pennsylvania Smell Identification Test (UPSIT) scores in LRRK2-G2019S-PD were higher than those in IPD (23.5±6.8 vs 18.4±6.0; p = 0.002), and hyposmia was less frequent in G2019S carriers than in IPD (39.4% vs 75.8%; p = 0.01). UPSIT scores were significantly higher in females than in males in LRRK2-PD patients (26.9±4.7 vs 19.4±6.8; p |
| doi_str_mv | 10.1371/journal.pone.0108982 |
| format | article |
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To evaluate the prevalence and time of onset of nonmotor symptoms (NMS) in LRRK2-PD patients.
The presence of hyposmia and of neuropsychiatric, dysautonomic and sleep disturbances was assessed in 33 LRRK2-G2019S-PD patients by standardized questionnaires and validated scales. Thirty-three IPD patients, matched for age, gender, duration of parkinsonism and disease severity and 33 healthy subjects were also evaluated.
University of Pennsylvania Smell Identification Test (UPSIT) scores in LRRK2-G2019S-PD were higher than those in IPD (23.5±6.8 vs 18.4±6.0; p = 0.002), and hyposmia was less frequent in G2019S carriers than in IPD (39.4% vs 75.8%; p = 0.01). UPSIT scores were significantly higher in females than in males in LRRK2-PD patients (26.9±4.7 vs 19.4±6.8; p<0.01). The frequency of sleep and neuropsychiatric disturbances and of dysautonomic symptoms in LRRK2-G2019S-PD was not significantly different from that in IPD. Hyposmia, depression, constipation and excessive daytime sleepiness, were reported to occur before the onset of classical motor symptoms in more than 40% of LRRK2-PD patients in whom these symptoms were present at the time of examination.
Neuropsychiatric, dysautonomic and sleep disturbances occur as frequently in patients with LRRK2-G2019S-PD as in IPD but smell loss was less frequent in LRRK2-PD. Like in IPD, disturbances such as hyposmia, depression, constipation and excessive daytime sleepiness may antedate the onset of classical motor symptoms in LRRK2-G2019S-PD.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0108982</identifier><identifier>PMID: 25330404</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Aged ; Basal ganglia ; Brain diseases ; Brain research ; Case-Control Studies ; Central nervous system diseases ; Constipation ; Constipation - complications ; Constipation - diagnosis ; Daytime ; Dementia ; Depression (Mood disorder) ; Depression - complications ; Depression - diagnosis ; Disturbances ; Family medical history ; Female ; Females ; Gender ; Hospitals ; Humans ; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 ; LRRK2 protein ; Male ; Males ; Medicine and Health Sciences ; Mental depression ; Middle Aged ; Movement disorders ; Mutation ; Mutation, Missense ; Neurology ; Neuropathology ; Olfaction Disorders - complications ; Olfaction Disorders - diagnosis ; Parkinson Disease - complications ; Parkinson Disease - diagnosis ; Parkinson Disease - genetics ; Parkinson's disease ; Pathology ; Patients ; Protein-Serine-Threonine Kinases - genetics ; Psychiatry ; Sex differences ; Sex Factors ; Sleep ; Sleep and wakefulness ; Sleep disorders ; Sleep Wake Disorders - complications ; Sleep Wake Disorders - diagnosis ; Sleepiness ; Smell ; Substantia nigra ; Substrates</subject><ispartof>PloS one, 2014-10, Vol.9 (10), p.e108982-e108982</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Gaig et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Gaig et al 2014 Gaig et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c758t-f909c08cc14e96f9ed47937891f6f3bea56529d6b34478d9778e85a391fd10233</citedby><cites>FETCH-LOGICAL-c758t-f909c08cc14e96f9ed47937891f6f3bea56529d6b34478d9778e85a391fd10233</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1613424219/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1613424219?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25330404$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Duda, John</contributor><creatorcontrib>Gaig, Carles</creatorcontrib><creatorcontrib>Vilas, Dolores</creatorcontrib><creatorcontrib>Infante, Jon</creatorcontrib><creatorcontrib>Sierra, María</creatorcontrib><creatorcontrib>García-Gorostiaga, Inés</creatorcontrib><creatorcontrib>Buongiorno, Mariateresa</creatorcontrib><creatorcontrib>Ezquerra, Mario</creatorcontrib><creatorcontrib>Martí, Maria José</creatorcontrib><creatorcontrib>Valldeoriola, Francesc</creatorcontrib><creatorcontrib>Aguilar, Miquel</creatorcontrib><creatorcontrib>Calopa, Matilde</creatorcontrib><creatorcontrib>Hernandez-Vara, Jorge</creatorcontrib><creatorcontrib>Tolosa, Eduardo</creatorcontrib><title>Nonmotor symptoms in LRRK2 G2019S associated Parkinson's disease</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Idiopathic Parkinson's disease (IPD) and LRRK2-associated PD (LRRK2-PD) might be expected to differ clinically since the neuropathological substrate of LRRK2-PD is heterogeneous. The range and severity of extra-nigral nonmotor features associated with LRRK2 mutations is also not well-defined.
To evaluate the prevalence and time of onset of nonmotor symptoms (NMS) in LRRK2-PD patients.
The presence of hyposmia and of neuropsychiatric, dysautonomic and sleep disturbances was assessed in 33 LRRK2-G2019S-PD patients by standardized questionnaires and validated scales. Thirty-three IPD patients, matched for age, gender, duration of parkinsonism and disease severity and 33 healthy subjects were also evaluated.
University of Pennsylvania Smell Identification Test (UPSIT) scores in LRRK2-G2019S-PD were higher than those in IPD (23.5±6.8 vs 18.4±6.0; p = 0.002), and hyposmia was less frequent in G2019S carriers than in IPD (39.4% vs 75.8%; p = 0.01). UPSIT scores were significantly higher in females than in males in LRRK2-PD patients (26.9±4.7 vs 19.4±6.8; p<0.01). The frequency of sleep and neuropsychiatric disturbances and of dysautonomic symptoms in LRRK2-G2019S-PD was not significantly different from that in IPD. Hyposmia, depression, constipation and excessive daytime sleepiness, were reported to occur before the onset of classical motor symptoms in more than 40% of LRRK2-PD patients in whom these symptoms were present at the time of examination.
Neuropsychiatric, dysautonomic and sleep disturbances occur as frequently in patients with LRRK2-G2019S-PD as in IPD but smell loss was less frequent in LRRK2-PD. Like in IPD, disturbances such as hyposmia, depression, constipation and excessive daytime sleepiness may antedate the onset of classical motor symptoms in LRRK2-G2019S-PD.</description><subject>Aged</subject><subject>Basal ganglia</subject><subject>Brain diseases</subject><subject>Brain research</subject><subject>Case-Control Studies</subject><subject>Central nervous system diseases</subject><subject>Constipation</subject><subject>Constipation - complications</subject><subject>Constipation - diagnosis</subject><subject>Daytime</subject><subject>Dementia</subject><subject>Depression (Mood disorder)</subject><subject>Depression - complications</subject><subject>Depression - diagnosis</subject><subject>Disturbances</subject><subject>Family medical history</subject><subject>Female</subject><subject>Females</subject><subject>Gender</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Leucine-Rich Repeat Serine-Threonine Protein Kinase-2</subject><subject>LRRK2 protein</subject><subject>Male</subject><subject>Males</subject><subject>Medicine and Health Sciences</subject><subject>Mental depression</subject><subject>Middle Aged</subject><subject>Movement disorders</subject><subject>Mutation</subject><subject>Mutation, Missense</subject><subject>Neurology</subject><subject>Neuropathology</subject><subject>Olfaction Disorders - complications</subject><subject>Olfaction Disorders - diagnosis</subject><subject>Parkinson Disease - complications</subject><subject>Parkinson Disease - diagnosis</subject><subject>Parkinson Disease - genetics</subject><subject>Parkinson's disease</subject><subject>Pathology</subject><subject>Patients</subject><subject>Protein-Serine-Threonine Kinases - genetics</subject><subject>Psychiatry</subject><subject>Sex differences</subject><subject>Sex Factors</subject><subject>Sleep</subject><subject>Sleep and wakefulness</subject><subject>Sleep disorders</subject><subject>Sleep Wake Disorders - complications</subject><subject>Sleep Wake Disorders - diagnosis</subject><subject>Sleepiness</subject><subject>Smell</subject><subject>Substantia nigra</subject><subject>Substrates</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNqNkl1v0zAUhiMEYqPwDxBEQhpw0eKvOPYN2jTBqKgY6oBby3Gc1iWxi-0g9u9x12xq0C6QL2z5POf1Ocdvlj2HYAZxCd9tXO-tbGdbZ_UMQMA4Qw-yY8gxmlIE8MOD81H2JIQNAAVmlD7OjlCBMSCAHGenX5ztXHQ-D9fdNrou5Mbmi-XyM8ovEID8KpchOGVk1HX-VfqfxgZnX4e8NkHLoJ9mjxrZBv1s2CfZ948fvp1_mi4uL-bnZ4upKgsWpw0HXAGmFCSa04brmpQcl4zDhja40rKgBeI1rTAhJat5WTLNColTvIYAYTzJXu51t60LYmg-CEghJoig1Ookm--J2smN2HrTSX8tnDTi5sL5lZA-GtVqUQHMFVNEqUoRSpmslGqUbDhFqToOktb74bW-6nSttI1etiPRccSatVi534KkmZGiTAJvBgHvfvU6RNGZoHTbSqtdf1N3gSgscZHQV_-g93c3UCuZGjC2celdtRMVZwSyRBEOEzW7h0qr1p1RySmNSfejhLejhMRE_SeuZB-CmF8t_5-9_DFmTw7YtZZtXAfX9tE4G8Yg2YPKuxC8bu6GDIHYGf12GmJndDEYPaW9OPygu6RbZ-O_eLD1pA</recordid><startdate>20141017</startdate><enddate>20141017</enddate><creator>Gaig, Carles</creator><creator>Vilas, Dolores</creator><creator>Infante, Jon</creator><creator>Sierra, María</creator><creator>García-Gorostiaga, Inés</creator><creator>Buongiorno, Mariateresa</creator><creator>Ezquerra, Mario</creator><creator>Martí, Maria José</creator><creator>Valldeoriola, Francesc</creator><creator>Aguilar, Miquel</creator><creator>Calopa, Matilde</creator><creator>Hernandez-Vara, Jorge</creator><creator>Tolosa, Eduardo</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20141017</creationdate><title>Nonmotor symptoms in LRRK2 G2019S associated Parkinson's disease</title><author>Gaig, Carles ; Vilas, Dolores ; Infante, Jon ; Sierra, María ; García-Gorostiaga, Inés ; Buongiorno, Mariateresa ; Ezquerra, Mario ; Martí, Maria José ; Valldeoriola, Francesc ; Aguilar, Miquel ; Calopa, Matilde ; Hernandez-Vara, Jorge ; Tolosa, Eduardo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c758t-f909c08cc14e96f9ed47937891f6f3bea56529d6b34478d9778e85a391fd10233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aged</topic><topic>Basal ganglia</topic><topic>Brain diseases</topic><topic>Brain research</topic><topic>Case-Control Studies</topic><topic>Central nervous system diseases</topic><topic>Constipation</topic><topic>Constipation - complications</topic><topic>Constipation - diagnosis</topic><topic>Daytime</topic><topic>Dementia</topic><topic>Depression (Mood disorder)</topic><topic>Depression - complications</topic><topic>Depression - diagnosis</topic><topic>Disturbances</topic><topic>Family medical history</topic><topic>Female</topic><topic>Females</topic><topic>Gender</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Leucine-Rich Repeat Serine-Threonine Protein Kinase-2</topic><topic>LRRK2 protein</topic><topic>Male</topic><topic>Males</topic><topic>Medicine and Health Sciences</topic><topic>Mental depression</topic><topic>Middle Aged</topic><topic>Movement disorders</topic><topic>Mutation</topic><topic>Mutation, Missense</topic><topic>Neurology</topic><topic>Neuropathology</topic><topic>Olfaction Disorders - complications</topic><topic>Olfaction Disorders - diagnosis</topic><topic>Parkinson Disease - complications</topic><topic>Parkinson Disease - diagnosis</topic><topic>Parkinson Disease - genetics</topic><topic>Parkinson's disease</topic><topic>Pathology</topic><topic>Patients</topic><topic>Protein-Serine-Threonine Kinases - genetics</topic><topic>Psychiatry</topic><topic>Sex differences</topic><topic>Sex Factors</topic><topic>Sleep</topic><topic>Sleep and wakefulness</topic><topic>Sleep disorders</topic><topic>Sleep Wake Disorders - complications</topic><topic>Sleep Wake Disorders - diagnosis</topic><topic>Sleepiness</topic><topic>Smell</topic><topic>Substantia nigra</topic><topic>Substrates</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gaig, Carles</creatorcontrib><creatorcontrib>Vilas, Dolores</creatorcontrib><creatorcontrib>Infante, Jon</creatorcontrib><creatorcontrib>Sierra, María</creatorcontrib><creatorcontrib>García-Gorostiaga, Inés</creatorcontrib><creatorcontrib>Buongiorno, Mariateresa</creatorcontrib><creatorcontrib>Ezquerra, Mario</creatorcontrib><creatorcontrib>Martí, Maria José</creatorcontrib><creatorcontrib>Valldeoriola, Francesc</creatorcontrib><creatorcontrib>Aguilar, Miquel</creatorcontrib><creatorcontrib>Calopa, Matilde</creatorcontrib><creatorcontrib>Hernandez-Vara, Jorge</creatorcontrib><creatorcontrib>Tolosa, Eduardo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database (ProQuest)</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gaig, Carles</au><au>Vilas, Dolores</au><au>Infante, Jon</au><au>Sierra, María</au><au>García-Gorostiaga, Inés</au><au>Buongiorno, Mariateresa</au><au>Ezquerra, Mario</au><au>Martí, Maria José</au><au>Valldeoriola, Francesc</au><au>Aguilar, Miquel</au><au>Calopa, Matilde</au><au>Hernandez-Vara, Jorge</au><au>Tolosa, Eduardo</au><au>Duda, John</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nonmotor symptoms in LRRK2 G2019S associated Parkinson's disease</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2014-10-17</date><risdate>2014</risdate><volume>9</volume><issue>10</issue><spage>e108982</spage><epage>e108982</epage><pages>e108982-e108982</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Idiopathic Parkinson's disease (IPD) and LRRK2-associated PD (LRRK2-PD) might be expected to differ clinically since the neuropathological substrate of LRRK2-PD is heterogeneous. The range and severity of extra-nigral nonmotor features associated with LRRK2 mutations is also not well-defined.
To evaluate the prevalence and time of onset of nonmotor symptoms (NMS) in LRRK2-PD patients.
The presence of hyposmia and of neuropsychiatric, dysautonomic and sleep disturbances was assessed in 33 LRRK2-G2019S-PD patients by standardized questionnaires and validated scales. Thirty-three IPD patients, matched for age, gender, duration of parkinsonism and disease severity and 33 healthy subjects were also evaluated.
University of Pennsylvania Smell Identification Test (UPSIT) scores in LRRK2-G2019S-PD were higher than those in IPD (23.5±6.8 vs 18.4±6.0; p = 0.002), and hyposmia was less frequent in G2019S carriers than in IPD (39.4% vs 75.8%; p = 0.01). UPSIT scores were significantly higher in females than in males in LRRK2-PD patients (26.9±4.7 vs 19.4±6.8; p<0.01). The frequency of sleep and neuropsychiatric disturbances and of dysautonomic symptoms in LRRK2-G2019S-PD was not significantly different from that in IPD. Hyposmia, depression, constipation and excessive daytime sleepiness, were reported to occur before the onset of classical motor symptoms in more than 40% of LRRK2-PD patients in whom these symptoms were present at the time of examination.
Neuropsychiatric, dysautonomic and sleep disturbances occur as frequently in patients with LRRK2-G2019S-PD as in IPD but smell loss was less frequent in LRRK2-PD. Like in IPD, disturbances such as hyposmia, depression, constipation and excessive daytime sleepiness may antedate the onset of classical motor symptoms in LRRK2-G2019S-PD.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25330404</pmid><doi>10.1371/journal.pone.0108982</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2014-10, Vol.9 (10), p.e108982-e108982 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1613424219 |
| source | Open Access: PubMed Central; Publicly Available Content Database |
| subjects | Aged Basal ganglia Brain diseases Brain research Case-Control Studies Central nervous system diseases Constipation Constipation - complications Constipation - diagnosis Daytime Dementia Depression (Mood disorder) Depression - complications Depression - diagnosis Disturbances Family medical history Female Females Gender Hospitals Humans Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 LRRK2 protein Male Males Medicine and Health Sciences Mental depression Middle Aged Movement disorders Mutation Mutation, Missense Neurology Neuropathology Olfaction Disorders - complications Olfaction Disorders - diagnosis Parkinson Disease - complications Parkinson Disease - diagnosis Parkinson Disease - genetics Parkinson's disease Pathology Patients Protein-Serine-Threonine Kinases - genetics Psychiatry Sex differences Sex Factors Sleep Sleep and wakefulness Sleep disorders Sleep Wake Disorders - complications Sleep Wake Disorders - diagnosis Sleepiness Smell Substantia nigra Substrates |
| title | Nonmotor symptoms in LRRK2 G2019S associated Parkinson's disease |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T23%3A11%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Nonmotor%20symptoms%20in%20LRRK2%20G2019S%20associated%20Parkinson's%20disease&rft.jtitle=PloS%20one&rft.au=Gaig,%20Carles&rft.date=2014-10-17&rft.volume=9&rft.issue=10&rft.spage=e108982&rft.epage=e108982&rft.pages=e108982-e108982&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0108982&rft_dat=%3Cgale_plos_%3EA418424491%3C/gale_plos_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c758t-f909c08cc14e96f9ed47937891f6f3bea56529d6b34478d9778e85a391fd10233%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1613424219&rft_id=info:pmid/25330404&rft_galeid=A418424491&rfr_iscdi=true |