Incidence of rotavirus and circulating genotypes in Northeast Brazil during 7 years of national rotavirus vaccination

• Published in: PloS one 2014-10, Vol.9 (10), p.e110217-e110217
• Main Authors: Gurgel, Ricardo Q, Alvarez, Alberto De Juan, Rodrigues, Alda, Ribeiro, Robergson R, Dolabella, Sílvio S, Da Mota, Natanael L, Santos, Victor S, Iturriza-Gomara, Miren, Cunliffe, Nigel A, Cuevas, Luis E
• Format: Article
• Language: English
• Subjects: Age; Biology and Life Sciences; Brazil - epidemiology; Child; Child, Preschool; Children; Diarrhea; Drug dosages; Epidemiological Monitoring; Epidemiology; Ethics; Fatalities; Female; Genetic aspects; Genotype; Genotype & phenotype; Genotypes; Health aspects; Hospitals; Humans; Incidence; Infant; Infant, Newborn; Infections; Male; Medicine and Health Sciences; Mortality; Parents & parenting; Reduction; Rotavirus; Rotavirus - genetics; Rotavirus - immunology; Rotavirus - isolation & purification; Rotavirus - physiology; Seasonal variations; Surveillance; Surveys; Vaccination; Vaccines; Viruses
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0110217

Rotavirus causes severe diarrhoea and Brazil introduced the Rotarix G1P[8] vaccine in 2006. We aimed to describe changes in rotavirus incidence and diarrhoea epidemiology before and after vaccine introduction. (i) hospital-based survey of children with diarrhoea (2006-2012); (ii) diarrhea-mortality and hospitalization surveillance (1999-2012). (i) Aracaju and (ii) state and national level. 1841 children were enrolled and 231 (12.5%) had rotavirus. Rotavirus was less frequent from January-June than from July-December (9.4% versus 20.9%, p