The plasma B-type natriuretic peptide levels are low in males with stable ischemic heart disease (IHD) compared to those observed in patients with non-IHD: a retrospective study

Although the plasma B-type natriuretic peptide (BNP) level is a marker of heart failure, it is unclear whether BNP per se plays a pivotal role for pathogenic mechanisms underlying the development of ischemic heart disease (IHD). In this study, we retrospectively examined the plasma BNP levels in sta...

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Published in:PloS one 2014-10, Vol.9 (10), p.e108983-e108983
Main Authors: Minai, Kosuke, Ogawa, Takayuki, Kawai, Makoto, Komukai, Kimiaki, Tanaka, Toshikazu, Ogawa, Kazuo, Nagoshi, Tomohisa, Arase, Satoshi, Morimoto, Satoshi, Inoue, Yasunori, Sekiyama, Hiroshi, Urabe, Akihiro, Matsuo, Seiichiro, Hongo, Kenichi, Yoshimura, Michihiro
Format: Article
Language:English
Subjects:
Age
Aged
Angina pectoris
Atherosclerosis
Biomarkers - blood
Body mass
Body Mass Index
Body size
Brain natriuretic peptide
Cardiac Catheterization
Cardiology
Cardiovascular disease
Cardiovascular diseases
Cardiovascular Diseases - blood
Catheterization
Coronary artery disease
Coronary vessels
Creatinine
Family medical history
Female
Females
Fibrillation
Gender differences
Health risk assessment
Heart attacks
Heart diseases
Heart failure
Humans
Internal medicine
Intubation
Ischemia
Logistic Models
Male
Males
Medicine
Medicine and Health Sciences
Middle Aged
Multiple regression analysis
Myocardial Ischemia - blood
Myocardial Ischemia - physiopathology
Natriuretic Peptide, Brain - blood
Patients
Peptides
Physicians
Population studies
Regression Analysis
Regression coefficients
Retrospective Studies
Rodents
Ventricle
Ventricular Function, Left
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Summary:Although the plasma B-type natriuretic peptide (BNP) level is a marker of heart failure, it is unclear whether BNP per se plays a pivotal role for pathogenic mechanisms underlying the development of ischemic heart disease (IHD). In this study, we retrospectively examined the plasma BNP levels in stable patients with IHD and compared to stable patients with cardiovascular diseases other than IHD. The study population was 2088 patients (1698 males and 390 females) who were admitted to our hospital due to IHD (n = 1,661) and non-IHD (n = 427) and underwent cardiac catheterization. Measurements of the hemodynamic parameters and blood sampling were performed. The plasma BNP levels were significantly lower in the IHD group than in the non-IHD group (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0108983