Three minutes of all-out intermittent exercise per week increases skeletal muscle oxidative capacity and improves cardiometabolic health

We investigated whether a training protocol that involved 3 min of intense intermittent exercise per week--within a total training time commitment of 30 min including warm up and cool down--could increase skeletal muscle oxidative capacity and markers of health status. Overweight/obese but otherwise...

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Published in:PloS one 2014-11, Vol.9 (11), p.e111489-e111489
Main Authors: Gillen, Jenna B, Percival, Michael E, Skelly, Lauren E, Martin, Brian J, Tan, Rachel B, Tarnopolsky, Mark A, Gibala, Martin J
Format: Article
Language:English
Subjects:
Acyl-CoA dehydrogenase
Adaptation
Adaptation, Physiological
Adaptations
Adult
Adults
Biology and Life Sciences
Biopsy
Blood Glucose
Blood levels
Blood pressure
Body mass
Body mass index
Body size
Body weight
Citrate synthase
Cytochrome
Diabetes
Diet
Energy Metabolism
Enzymes
Exercise
Female
Fitness training programs
Gender differences
Glucose
Glucose monitoring
Health care
Health Status Indicators
Humans
Intervention
Kinesiology
Male
Males
Medicine and Health Sciences
Men
Mens health
Metabolism
Mitochondria - metabolism
Muscle, Skeletal - metabolism
Muscles
Musculoskeletal system
Myocardium - metabolism
Obesity - blood
Obesity - metabolism
Overweight
Overweight - blood
Overweight - metabolism
Oxidases
Oxygen
Oxygen Consumption
Oxygen uptake
Physical fitness
Physiology
Proteins
Public health
Skeletal muscle
Studies
Systematic review
Time Factors
Training
Warm up
Women
Young Adult
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Percival, Michael E
Skelly, Lauren E
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description We investigated whether a training protocol that involved 3 min of intense intermittent exercise per week--within a total training time commitment of 30 min including warm up and cool down--could increase skeletal muscle oxidative capacity and markers of health status. Overweight/obese but otherwise healthy men and women (n = 7 each; age = 29±9 y; BMI = 29.8±2.7 kg/m2) performed 18 training sessions over 6 wk on a cycle ergometer. Each session began with a 2 min warm-up at 50 W, followed by 3×20 s "all-out" sprints against 5.0% body mass (mean power output: ∼450-500 W) interspersed with 2 min of recovery at 50 W, followed by a 3 min cool-down at 50 W. Peak oxygen uptake increased by 12% after training (32.6±4.5 vs. 29.1±4.2 ml/kg/min) and resting mean arterial pressure decreased by 7% (78±10 vs. 83±10 mmHg), with no difference between groups (both p
doi_str_mv 10.1371/journal.pone.0111489
format article
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Overweight/obese but otherwise healthy men and women (n = 7 each; age = 29±9 y; BMI = 29.8±2.7 kg/m2) performed 18 training sessions over 6 wk on a cycle ergometer. Each session began with a 2 min warm-up at 50 W, followed by 3×20 s "all-out" sprints against 5.0% body mass (mean power output: ∼450-500 W) interspersed with 2 min of recovery at 50 W, followed by a 3 min cool-down at 50 W. Peak oxygen uptake increased by 12% after training (32.6±4.5 vs. 29.1±4.2 ml/kg/min) and resting mean arterial pressure decreased by 7% (78±10 vs. 83±10 mmHg), with no difference between groups (both p&lt;0.01, main effects for time). Skeletal muscle biopsy samples obtained before and 72 h after training revealed increased maximal activity of citrate synthase and protein content of cytochrome oxidase 4 (p&lt;0.01, main effect), while the maximal activity of β-hydroxy acyl CoA dehydrogenase increased in men only (p&lt;0.05). Continuous glucose monitoring measured under standard dietary conditions before and 48-72 h following training revealed lower 24 h average blood glucose concentration in men following training (5.4±0.6 vs. 5.9±0.5 mmol/L, p&lt;0.05), but not women (5.5±0.4 vs. 5.5±0.6 mmol/L). This was associated with a greater increase in GLUT4 protein content in men compared to women (138% vs. 23%, p&lt;0.05). Short-term interval training using a 10 min protocol that involved only 1 min of hard exercise, 3x/wk, stimulated physiological changes linked to improved health in overweight adults. 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minutes of all-out intermittent exercise per week increases skeletal muscle oxidative capacity and improves cardiometabolic health</title><author>Gillen, Jenna B ; Percival, Michael E ; Skelly, Lauren E ; Martin, Brian J ; Tan, Rachel B ; Tarnopolsky, Mark A ; Gibala, Martin J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c758t-a13524089ea5e35c78a583b57bf56f8fdab6931d45d10404b7366f13fc3138873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Acyl-CoA dehydrogenase</topic><topic>Adaptation</topic><topic>Adaptation, Physiological</topic><topic>Adaptations</topic><topic>Adult</topic><topic>Adults</topic><topic>Biology and Life Sciences</topic><topic>Biopsy</topic><topic>Blood Glucose</topic><topic>Blood levels</topic><topic>Blood pressure</topic><topic>Body mass</topic><topic>Body mass index</topic><topic>Body size</topic><topic>Body weight</topic><topic>Citrate 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oxidative capacity and improves cardiometabolic health</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2014-11-03</date><risdate>2014</risdate><volume>9</volume><issue>11</issue><spage>e111489</spage><epage>e111489</epage><pages>e111489-e111489</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>We investigated whether a training protocol that involved 3 min of intense intermittent exercise per week--within a total training time commitment of 30 min including warm up and cool down--could increase skeletal muscle oxidative capacity and markers of health status. Overweight/obese but otherwise healthy men and women (n = 7 each; age = 29±9 y; BMI = 29.8±2.7 kg/m2) performed 18 training sessions over 6 wk on a cycle ergometer. Each session began with a 2 min warm-up at 50 W, followed by 3×20 s "all-out" sprints against 5.0% body mass (mean power output: ∼450-500 W) interspersed with 2 min of recovery at 50 W, followed by a 3 min cool-down at 50 W. Peak oxygen uptake increased by 12% after training (32.6±4.5 vs. 29.1±4.2 ml/kg/min) and resting mean arterial pressure decreased by 7% (78±10 vs. 83±10 mmHg), with no difference between groups (both p&lt;0.01, main effects for time). Skeletal muscle biopsy samples obtained before and 72 h after training revealed increased maximal activity of citrate synthase and protein content of cytochrome oxidase 4 (p&lt;0.01, main effect), while the maximal activity of β-hydroxy acyl CoA dehydrogenase increased in men only (p&lt;0.05). Continuous glucose monitoring measured under standard dietary conditions before and 48-72 h following training revealed lower 24 h average blood glucose concentration in men following training (5.4±0.6 vs. 5.9±0.5 mmol/L, p&lt;0.05), but not women (5.5±0.4 vs. 5.5±0.6 mmol/L). This was associated with a greater increase in GLUT4 protein content in men compared to women (138% vs. 23%, p&lt;0.05). Short-term interval training using a 10 min protocol that involved only 1 min of hard exercise, 3x/wk, stimulated physiological changes linked to improved health in overweight adults. Despite the small sample size, potential sex-specific adaptations were apparent that warrant further investigation.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25365337</pmid><doi>10.1371/journal.pone.0111489</doi><oa>free_for_read</oa></addata></record>
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identifier ISSN: 1932-6203
ispartof PloS one, 2014-11, Vol.9 (11), p.e111489-e111489
issn 1932-6203
1932-6203
language eng
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source Publicly Available Content Database; PubMed Central
subjects Acyl-CoA dehydrogenase
Adaptation
Adaptation, Physiological
Adaptations
Adult
Adults
Biology and Life Sciences
Biopsy
Blood Glucose
Blood levels
Blood pressure
Body mass
Body mass index
Body size
Body weight
Citrate synthase
Cytochrome
Diabetes
Diet
Energy Metabolism
Enzymes
Exercise
Female
Fitness training programs
Gender differences
Glucose
Glucose monitoring
Health care
Health Status Indicators
Humans
Intervention
Kinesiology
Male
Males
Medicine and Health Sciences
Men
Mens health
Metabolism
Mitochondria - metabolism
Muscle, Skeletal - metabolism
Muscles
Musculoskeletal system
Myocardium - metabolism
Obesity - blood
Obesity - metabolism
Overweight
Overweight - blood
Overweight - metabolism
Oxidases
Oxygen
Oxygen Consumption
Oxygen uptake
Physical fitness
Physiology
Proteins
Public health
Skeletal muscle
Studies
Systematic review
Time Factors
Training
Warm up
Women
Young Adult
title Three minutes of all-out intermittent exercise per week increases skeletal muscle oxidative capacity and improves cardiometabolic health
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