CD117 expression in fibroblasts-like stromal cells indicates unfavorable clinical outcomes in ovarian carcinoma patients

The stem cell factor (SCF) receptor CD117 (c-kit), is widely used for identification of hematopoietic stem cells and cancer stem cells. Moreover, CD117 expression in carcinoma cells indicates a poor prognosis in a variety of cancers. However the potential expression in tumor microenvironment and the...

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Bibliographic Details
Published in:PloS one 2014-11, Vol.9 (11), p.e112209-e112209
Main Authors: Huang, Ruixia, Wu, Dan, Yuan, Yuan, Li, Xiaoran, Holm, Ruth, Trope, Claes G, Nesland, Jahn M, Suo, Zhenhe
Format: Article
Language:English
Subjects:
Actin
Adult
Aged
Aged, 80 and over
Biology and Life Sciences
Bone marrow
c-Kit protein
Cancer
Carcinoma
CD73 antigen
Clinical medicine
Clinical outcomes
Departments
Disease-Free Survival
Endometrial cancer
Female
Fibroblast activation protein
Fibroblasts
Fibroblasts - pathology
Gene expression
Gynecology
Hematopoietic stem cells
Hospitals
Humans
Kaplan-Meier Estimate
Kinases
Medicine
Medicine and Health Sciences
Mesenchymal stem cells
Mesenchyme
Middle Aged
Muscles
Ovarian cancer
Ovarian carcinoma
Ovarian Neoplasms - diagnosis
Ovarian Neoplasms - pathology
Ovary - pathology
Pathology
Patient outcomes
Prognosis
Proto-Oncogene Proteins c-kit - analysis
Quality
Smooth muscle
Stem cell factor
Stem cells
Stromal cells
Stromal Cells - pathology
Survival
Tumors
Young Adult
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Summary:The stem cell factor (SCF) receptor CD117 (c-kit), is widely used for identification of hematopoietic stem cells and cancer stem cells. Moreover, CD117 expression in carcinoma cells indicates a poor prognosis in a variety of cancers. However the potential expression in tumor microenvironment and the biological and clinical impact are currently not reported. The expression of CD117 was immunohistochemically evaluated in a serial of 242 epithelial ovarian cancer (EOC) cases. Thirty-eight out of 242 cases were CD117 positive in fibroblast-like stromal cells and 22 cases were positive in EOC cells. Four cases were both positive in fibroblast-like stromal cells and EOC cells for CD117. CD117 expression in fibroblast-like stromal cells in ovarian carcinoma was closely linked to advanced FIGO stage, poor differentiation grade and histological subtype (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0112209