Advanced glycation endproducts interfere with adhesion and neurite outgrowth

Advanced glycation endproducts (AGEs) represent a non-enzymatic posttranslational protein modification. AGEs are generated by a series of chemical reactions of free reducing monosaccharides, such as glucose, fructose or metabolites of the monosaccharide metabolism with amino groups of proteins. Afte...

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Published in:PloS one 2014-11, Vol.9 (11), p.e112115-e112115
Main Authors: Bennmann, Dorit, Horstkorte, Rüdiger, Hofmann, Britt, Jacobs, Kathleen, Navarrete-Santos, Alexander, Simm, Andreas, Bork, Kaya, Gnanapragassam, Vinayaga S
Format: Article
Language:English
Subjects:
Adhesion
Advanced glycosylation end products
Age
Aging
Amino acids
Amino groups
Animals
Apoptosis - drug effects
Apoptosis - physiology
Axonogenesis
Biology and Life Sciences
Biomarkers
Blood levels
Carbonyl compounds
Carbonyls
Cell adhesion & migration
Cell Adhesion - drug effects
Cell Adhesion - physiology
Cell culture
Chemical reactions
Collagen
Collagen - metabolism
Dehydration
Diabetes mellitus
Diabetics
Disease
Enzymes
Extracellular matrix
Fructose
Glucose
Glycation End Products, Advanced - metabolism
Glycosylation
Growth factors
Kinases
Laminin
Laminin - metabolism
Life sciences
Metabolism
Metabolites
Monosaccharides
Nerve growth factor
Nerve Growth Factor - pharmacology
Neurites - drug effects
Neurites - metabolism
Neuroplasticity
Oxidation
Pathogenesis
PC12 Cells
Pheochromocytoma cells
Phosphorylation
Physiological aspects
Plasticity (neural)
Proteins
Pyruvaldehyde
Rats
Rodents
Signal transduction
Tissues
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cited_by cdi_FETCH-LOGICAL-c692t-32b4f0725ed1b81679133a51b2f58b1566506cfa8bf8cda6dbd79b49099f23a03
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container_issue 11
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container_title PloS one
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creator Bennmann, Dorit
Horstkorte, Rüdiger
Hofmann, Britt
Jacobs, Kathleen
Navarrete-Santos, Alexander
Simm, Andreas
Bork, Kaya
Gnanapragassam, Vinayaga S
description Advanced glycation endproducts (AGEs) represent a non-enzymatic posttranslational protein modification. AGEs are generated by a series of chemical reactions of free reducing monosaccharides, such as glucose, fructose or metabolites of the monosaccharide metabolism with amino groups of proteins. After oxidation, dehydration and condensation, stable AGE-modifications are formed. AGE-modified proteins accumulate in all cells and tissues as a normal feature of ageing and correlate with the glucose concentration in the blood. AGEs are increased in diabetic patients and play a significant role in the pathogenesis of most age-related neural disorders, such as Alzheimer's disease. We examined the role of AGEs on neurite outgrowth of PC12 cells. We induced the formation of AGEs using the reactive carbonyl compound methylglyoxal (MGO) as a physiological metabolite of glucose. We found that AGE-modification of laminin or collagen interfered with adhesion but not with neurite outgrowth of PC12 cells. Furthermore, the AGE-modification of PC12 cell proteins reduced NGF-induced neurite outgrowth. In conclusion, our data show that AGEs negatively influence neural plasticity.
doi_str_mv 10.1371/journal.pone.0112115
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subjects Adhesion
Advanced glycosylation end products
Age
Aging
Amino acids
Amino groups
Animals
Apoptosis - drug effects
Apoptosis - physiology
Axonogenesis
Biology and Life Sciences
Biomarkers
Blood levels
Carbonyl compounds
Carbonyls
Cell adhesion & migration
Cell Adhesion - drug effects
Cell Adhesion - physiology
Cell culture
Chemical reactions
Collagen
Collagen - metabolism
Dehydration
Diabetes mellitus
Diabetics
Disease
Enzymes
Extracellular matrix
Fructose
Glucose
Glycation End Products, Advanced - metabolism
Glycosylation
Growth factors
Kinases
Laminin
Laminin - metabolism
Life sciences
Metabolism
Metabolites
Monosaccharides
Nerve growth factor
Nerve Growth Factor - pharmacology
Neurites - drug effects
Neurites - metabolism
Neuroplasticity
Oxidation
Pathogenesis
PC12 Cells
Pheochromocytoma cells
Phosphorylation
Physiological aspects
Plasticity (neural)
Proteins
Pyruvaldehyde
Rats
Rodents
Signal transduction
Tissues
title Advanced glycation endproducts interfere with adhesion and neurite outgrowth
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